Department of Precision Medicine and Ionian Area, Section of Pharmacology, School of Medicine, University of Bari "Aldo Moro," Policlinico University Hospital of Bari, Bari, Italy.
Interdisciplinary Department of Medicine, School of Medicine, University of Bari "Aldo Moro", Bari, Italy.
Endocr Metab Immune Disord Drug Targets. 2024;24(15):1756-1773. doi: 10.2174/0118715303270923240307120117.
Panax ginseng is one of the most important remedies in ancient Eastern medicine. In the modern Western world, its reputation started to grow towards the end of the XIX century, but the rather approximate understanding of action mechanisms did not provide sufficient information for an appropriate use. Nowadays, is frequently used in some pathological conditions, but the comprehension of its potential beneficial effects is still incomplete. The purpose of this study is to highlight the most recent knowledge on mechanisms and effects of ginseng active ingredients on the intestinal microbiota. The human microbiota takes part in the immune and metabolic balance and serves as the most important regulator for the control of local pathogens. This delicate role requires a complex interaction and reflects the interconnection with the brainand the liver-axes. Thus, by exerting their beneficial effects through the intestinal microbiota, the active ingredients of (glycosides and their metabolites) might help to ameliorate both specific intestinal conditions as well as the whole organism's homeostasis.
人参是古代东方医学中最重要的药物之一。在现代西方世界，它的声誉始于 19 世纪末，但对作用机制的理解相当粗略，无法提供适当使用的充分信息。如今，人参在一些病理情况下经常被使用，但对其潜在有益作用的理解仍不完整。本研究的目的是强调人参活性成分对肠道微生物群的作用机制和影响的最新知识。人类微生物群参与免疫和代谢平衡，是控制局部病原体的最重要调节剂。这种微妙的作用需要复杂的相互作用，并反映了与大脑和肝脏轴的相互联系。因此，通过通过肠道微生物群发挥其有益作用，人参（苷及其代谢物）的活性成分可能有助于改善特定的肠道状况以及整个机体的内稳态。
