Amin Ruhul, Rancan Fiorenza, Hillmann Kathrin, Blume-Peytavi Ulrike, Vogt Annika, Kottner Jan
Department of Dermatology, Venereology and Allergology, Clinical Research Center for Hair and Skin Science, Charitéplatz 1, Charité-Universitätsmedizin Berlin corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.
BCSIR Laboratories Dhaka Bangladesh Council of Scientific and Industrial Research Dhaka Bangladesh.
Health Sci Rep. 2024 Mar 19;7(3):e1985. doi: 10.1002/hsr2.1985. eCollection 2024 Mar.
Skin aging is associated with dry skin and a decrease of the strength of the dermoepidermal adhesion, which increases the risk for lacerations (skin tears). Application of leave-on products improves dry skin and seems to reduce skin tear incidence. The aim of this study was to measure the effects of a humectant containing leave-on product on the strength of the dermoepidermal junction in older adult participants with dry skin.
A randomized controlled trial using a split body design was conducted. One forearm was randomly selected and treated with a lipophilic leave-on product containing 5% urea for 8 weeks. The other forearm was the control. The parameters stratum corneum hydration (SCH), transepidermal water loss, pH, roughness, epidermal thickness and skin stiffness were measured at the baseline, Weeks 4 and 8. At Week 8, suction blisters were created and time to blistering was measured. Blister roofs and interstitial fluid were analyzed for Interleukin-1α, 6 and 8.
Twelve participants were included. After 8 weeks treatment, SCH was higher (median difference 11.6 AU), and the overall dry skin score (median difference -1) and median roughness (Rz difference -12.2 µm) were lower compared to the control arms. The median group difference for Interleukin-1α was -452 fg/µg total protein (TP) in the blister roofs and -2.2 fg/µg TP in the blister fluids. The median time to blister formation was 7.7 min higher compared to the control arms.
The regular application of humectant containing leave-on products improves dry skin and seems to lower inflammation and contribute to the strengthening of the dermoepidermal adhesion. This partly explains how the use of topical leave-on products helps to prevent skin tears.
皮肤老化与皮肤干燥以及真皮表皮黏附力下降有关，这会增加撕裂伤（皮肤撕裂）的风险。涂抹型产品的使用可改善皮肤干燥状况，且似乎能降低皮肤撕裂的发生率。本研究的目的是测量一种含保湿剂的涂抹型产品对皮肤干燥的老年参与者真皮表皮连接处强度的影响。
采用随机对照试验，采用分体设计。随机选择一侧前臂，使用含5%尿素的亲脂性涂抹型产品治疗8周。另一侧前臂作为对照。在基线、第4周和第8周测量角质层水合作用（SCH）、经表皮水分流失、pH值、粗糙度、表皮厚度和皮肤硬度等参数。在第8周时，制造抽吸水疱并测量水疱形成时间。分析水疱顶部和间质液中的白细胞介素-1α、6和8。
纳入12名参与者。治疗8周后，与对照侧相比，SCH更高（中位数差异11.6 AU），总体皮肤干燥评分（中位数差异-1）和中位数粗糙度（Rz差异-12.2 µm）更低。水疱顶部白细胞介素-1α的中位数组间差异为-452 fg/µg总蛋白（TP），水疱液中为-2.2 fg/µg TP。与对照侧相比，水疱形成的中位数时间长7.7分钟。
定期使用含保湿剂的涂抹型产品可改善皮肤干燥状况，似乎还能减轻炎症并有助于增强真皮表皮黏附力。这部分解释了局部涂抹型产品的使用有助于预防皮肤撕裂的原因。
