Kottner Jan, Kanti Varvara, Dobos Gabor, Hahnel Elisabeth, Lichterfeld-Kottner Andrea, Richter Claudia, Hillmann Kathrin, Vogt Annika, Blume-Peytavi Ulrike
Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Int J Nurs Stud. 2017 Jan;65:17-24. doi: 10.1016/j.ijnurstu.2016.10.010. Epub 2016 Oct 26.
Dry skin (xerosis cutis) is increasingly recognized as a relevant health problem in daily life and in health and nursing care. The use of bath additives such as oils is common to reduce dry skin, but empirical evidence supporting this practice is limited.
The aim of this study was to investigate the effectiveness of using a bath oil additive in improving skin barrier function and ameliorating dry skin in comparison to non-oil containing skin cleansers for bathing or showering.
Single centre randomized observer blind pragmatic parallel group trial.
Outpatient/community care.
Volunteers showing clinically mild to moderate dry skin recruited from the city of Berlin.
Healthy children and adults were randomly assigned to use either a commercially available bath oil or to continue using their regular non-oil containing skin cleansers every other day over a study period of 28days. Skin barrier parameters and the severity of dry skin were assessed at baseline and at two follow-up visits at the study centre. Transepidermal water loss was the primary outcome.
All sixty participants randomized completed the trial. Median age was 32.5 (IQR 8.3 to 69) years. At the end of study the mean transepidermal water loss in the intervention group was statistically significant lower compared to the control group (mean difference -1.9 (95% CI -3.1 to -0.8) g/m/h). Stratum corneum hydration was statistically significantly higher in the intervention group at the end of the study. Skin surface pH and roughness were comparable in both groups and remained unchanged, while both groups showed a trend to improvement in dry skin symptoms CONCLUSIONS: This pragmatic trial provides empirical evidence that the regular use of the investigated bath oil is effective in improving the skin barrier function in children and adults with mild dry skin when used in routine skin care and supports its use as a basic element for the management of a broad spectrum of dry skin conditions.
ClinicalTrials.gov Identifier NCT02557698.
干性皮肤（皮肤干燥症）日益被视为日常生活以及健康和护理领域中的一个重要健康问题。使用油类等沐浴添加剂来减少干性皮肤很常见，但支持这种做法的实证证据有限。
本研究的目的是与不含油的沐浴或淋浴用皮肤清洁剂相比，调查使用沐浴油添加剂在改善皮肤屏障功能和缓解干性皮肤方面的有效性。
单中心随机观察者盲法实用平行组试验。
门诊/社区护理。
从柏林市招募的临床诊断为轻度至中度干性皮肤的志愿者。
健康儿童和成人被随机分配，在28天的研究期间每隔一天使用市售沐浴油，或继续使用其常规不含油的皮肤清洁剂。在研究中心的基线和两次随访时评估皮肤屏障参数和干性皮肤的严重程度。经表皮水分流失是主要结果。
随机分组的所有60名参与者均完成了试验。中位年龄为32.5岁（四分位间距8.3至69岁）。在研究结束时，干预组的平均经表皮水分流失与对照组相比有统计学意义的降低（平均差值-1.9（95%置信区间-3.1至-0.8）g/m/h）。在研究结束时，干预组的角质层水合作用有统计学意义的升高。两组的皮肤表面pH值和粗糙度相当且保持不变，而两组的干性皮肤症状均有改善趋势。结论：这项实用试验提供了实证证据，即在所调查的常规皮肤护理中，定期使用沐浴油对改善轻度干性皮肤儿童和成人的皮肤屏障功能有效，并支持将其作为广泛干性皮肤状况管理的基本要素使用。
ClinicalTrials.gov标识符NCT02557698。
