血清吲哚-3-丙酸水平与急性缺血性脑卒中进展及预后的相关性研究。

Study on the correlation between serum indole-3-propionic acid levels and the progression and prognosis of acute ischemic stroke.

机构信息

Clinical Medical College of Yangzhou University, Yangzhou, 225001, China; Department of Neurology, Northern Jiangsu People's Hospital, Yangzhou, 225001, China.

Clinical Medical College of Yangzhou University, Yangzhou, 225001, China; Department of Neurology, Northern Jiangsu People's Hospital, Yangzhou, 225001, China; Department of Neuro Intensive Care Unit, Northern Jiangsu People's Hospital, Yangzhou, 225001, China.

出版信息

J Stroke Cerebrovasc Dis. 2024 Jun;33(6):107680. doi: 10.1016/j.jstrokecerebrovasdis.2024.107680. Epub 2024 Mar 18.

DOI:10.1016/j.jstrokecerebrovasdis.2024.107680

PMID:38508478

Abstract

OBJECTIVE

This study aimed to explore the correlation between the serum level of indole-3-propionic acid (IPA) and the progression and prognosis of acute cerebral infarction (ACI).

METHODS

This study enrolled 197 patients with ACI, and 53 participants from a community-based stroke screening program during the same period were included as the control group. The patients with ACI were divided into quartiles of serum IPA. A logistic regression model was used for comparison. Receiver operating characteristic (ROC) curves were drawn to evaluate the predictive value of the IPA.

RESULTS

Compared with the healthy control group, the ACI group had lower serum IPA (P < 0.05). The serum IPA was an independent factor for acute ischemic stroke (OR=0.992, 95% CI: 0.984-0.999, P=0.035). The serum IPA was lower in patients with progressive stroke or poor prognosis than in patients with stable stroke or good prognosis (P < 0.05). Patients with ACI with low serum IPA are prone to progression and poor prognosis. The best cutoff value for predicting progression was 193.62 pg/mL (sensitivity, 67.5%; specificity 83.7%), and that for poor prognosis was 193.77 pg/mL (sensitivity, 71.1%; specificity, 72.5%).

CONCLUSION

The serum level of IPA was an independent predictor of ACI and had certain clinical value for predicting stroke progression and prognosis in patients with ACI.

摘要

目的

本研究旨在探讨血清吲哚-3-丙酸（IPA）水平与急性脑梗死（ACI）进展和预后的相关性。

方法

本研究纳入了 197 例 ACI 患者，同期纳入了 53 例来自社区脑卒中筛查项目的参与者作为对照组。将 ACI 患者按血清 IPA 四分位数进行分组，采用 logistic 回归模型进行比较。绘制受试者工作特征（ROC）曲线评估 IPA 的预测价值。

结果

与健康对照组相比，ACI 组血清 IPA 水平较低（P＜0.05）。血清 IPA 是急性缺血性脑卒中的独立因素（OR＝0.992，95％CI：0.984～0.999，P＝0.035）。进展性脑卒中或预后不良患者的血清 IPA 低于稳定性脑卒中或预后良好患者（P＜0.05）。血清 IPA 水平较低的 ACI 患者易发生进展和预后不良。预测进展的最佳截断值为 193.62 pg/mL（灵敏度 67.5％，特异性 83.7％），预测预后不良的最佳截断值为 193.77 pg/mL（灵敏度 71.1％，特异性 72.5％）。