Huang Tianxiang, Inomata Takenori, Sung Jaemyoung, Yoshida Naoko, Ishida Gaku, Ohara Hitomi, Yamaguchi Masahiro, Akasaki Yasutsugu, Okumura Yuichi, Nagino Ken, Hirosawa Kunihiko, Mita Toshihiro, Nakao Shintaro, Ishida Nobuo
Juntendo University Graduate School of Medicine, Department of Ophthalmology, Tokyo, Japan.
Juntendo University Graduate School of Medicine, Department of Digital Medicine, Tokyo, Japan.
Am J Ophthalmol Case Rep. 2024 Mar 9;34:102030. doi: 10.1016/j.ajoc.2024.102030. eCollection 2024 Jun.
We report the clinical findings and molecular identification of ocular from Niigata Prefecture in the Hokuriku area of Japan during winter.
A 77-year-old male visited an ophthalmology clinic in Niigata Prefecture in January 2022 after a 2-week-duration of a conjunctival injection in the left eye and foreign body sensation. Slit-lamp microscopy revealed 11 active nematodes in the left conjunctival sac. Morphological characteristics included longer female body length than male, buccal cavity lacking teeth and lips, and serrated striations along the body surface. The specimens were determined to be . Genetic analysis of the mitochondrial cytochrome oxidase subunit 1 () gene revealed an h9 haplotype.
infection, especially the h9 haplotype, commonly occurs in western Japan owing to its higher incidence in warmer climates, suggesting the origin of the case. Here, we report a human case of diagnosed in a cold region of Japan (the Hokuriku area) during winter. This human case of infection from a cold, previously unassociated region, raises concerns about the potential geographical widening of its distribution, and further investigation may be warranted to prevent its spread.
我们报告了日本北陆地区新潟县冬季眼部感染的临床发现和分子鉴定结果。
一名77岁男性在左眼结膜充血和有异物感持续2周后，于2022年1月前往新潟县的一家眼科诊所就诊。裂隙灯显微镜检查发现左眼结膜囊内有11条活动的线虫。形态学特征包括雌虫体长大于雄虫，口腔无齿和唇，体表有锯齿状条纹。这些标本被鉴定为[未提及具体线虫种类，无法准确翻译]。线粒体细胞色素c氧化酶亚基1（[未提及具体基因名称，无法准确翻译]）基因的遗传分析显示为h9单倍型。
[未提及具体线虫种类，无法准确翻译]感染，尤其是h9单倍型，在日本西部较为常见，因为其在温暖气候下发病率较高，这表明了该病例的来源。在此，我们报告了一例冬季在日本寒冷地区（北陆地区）诊断出的[未提及具体线虫种类，无法准确翻译]人类病例。这例来自寒冷且此前未关联地区的[未提及具体线虫种类，无法准确翻译]人类感染病例，引发了对其分布可能在地理上扩大的担忧，可能需要进一步调查以防止其传播。
