Chauhan Sakshi, Mathur Runjhun, Jha Abhimanyu Kumar
Department of Biotechnology, Sharda University, Greater Noida, Uttar Pradesh, India.
Dr APJ Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India.
Mol Biotechnol. 2025 Mar;67(3):845-861. doi: 10.1007/s12033-024-01113-w. Epub 2024 Mar 21.
Breast cancer is considered a significant health concern worldwide, with genetic predisposition playing a critical role in its etiology. Single nucleotide polymorphisms (SNPs), particularly those within the 3' untranslated regions (3'UTRs) of target genes, are emerging as key factors in breast cancer susceptibility. Specifically, miRNAs have been recognized as possible novel approach for biomarkers discovery for both prognosis and diagnosis due to their direct association with cancer progression. Regional disparities in breast cancer incidence underscore the need for precise interventions, considering socio-cultural and economic factors. This review explores into the differential effects of SNP-miRNA interactions on breast cancer risk, emphasizing both risk-enhancing and protective associations across diverse populations. Furthermore, it explores the clinical implications of these findings, highlighting the potential of personalized approaches in breast cancer management. Additionally, it reviews the evolving therapeutic prospect of microRNAs (miRNAs), extending beyond cancer therapeutics to encompass various diseases, indicative of their versatility as therapeutic agents.
乳腺癌被认为是全球重大的健康问题，遗传易感性在其病因中起着关键作用。单核苷酸多态性（SNP），尤其是靶基因3'非翻译区（3'UTR）内的那些多态性，正成为乳腺癌易感性的关键因素。具体而言，由于miRNA与癌症进展直接相关，它们已被认为是发现用于预后和诊断的生物标志物的一种可能的新方法。考虑到社会文化和经济因素，乳腺癌发病率的地区差异凸显了精准干预的必要性。本综述探讨了SNP-miRNA相互作用对乳腺癌风险的不同影响，强调了不同人群中增加风险和具有保护作用的关联。此外，还探讨了这些发现的临床意义，突出了个性化方法在乳腺癌管理中的潜力。此外，综述了微小RNA（miRNA）不断发展的治疗前景，其已超越癌症治疗领域，涵盖各种疾病，表明它们作为治疗剂具有多功能性。
