用于个性化医疗的纳米颗粒物理化学性质的精确控制方法。
Precise control methods of the physicochemical properties of nanoparticles for personalized medicine.
机构信息
Institute of Engineering Innovation, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-8656, Japan; Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Institute of Engineering Innovation, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-8656, Japan; Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; Department of Chemical System Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.
出版信息
Curr Opin Biotechnol. 2024 Jun;87:103108. doi: 10.1016/j.copbio.2024.103108. Epub 2024 Mar 20.
Biomedical applications of nanoparticles (NPs) have attracted much attention. With the advancement of personalized medicine, researchers are now proposing the concept that the design of NPs needs to be optimized according to the individual patient. To realize this concept, an important question is how precisely we can tailor the physicochemical properties of NPs, such as size, shape, and surface chemistry, using current technology. This review discusses recent advances and challenges in the precise control of the size, shape, and surface chemistry of NPs. While control methods have advanced significantly over the past 20 years, the size, shape, and surface chemistry of currently available NPs vary by type, requiring careful selection based on the targeted disease, organ, and patient.
纳米粒子 (NPs) 在生物医学中的应用引起了广泛关注。随着个性化医疗的发展，研究人员现在提出了这样的概念，即需要根据个体患者来优化 NPs 的设计。为了实现这一概念，一个重要的问题是我们目前可以使用何种技术精确地调整 NPs 的物理化学性质，例如大小、形状和表面化学性质。本文综述了近年来在精确控制 NPs 的大小、形状和表面化学性质方面的进展和挑战。虽然在过去的 20 年中，控制方法已经取得了显著的进步，但目前可用的 NPs 的大小、形状和表面化学性质因类型而异，需要根据目标疾病、器官和患者进行仔细选择。
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