Department of Physiology, Armed Forces Medical College, Pune, Maharashtra, India.
High Altitude Medical Research Centre, Leh, Ladakh, India.
Indian J Med Res. 2024 Feb 1;159(2):241-245. doi: 10.4103/ijmr.ijmr_2127_21. Epub 2024 Apr 4.
High-altitude headache (HAH) and headache in acute mountain sickness (AMS) are common among lowlanders ascending to the high altitude and are often confused with one another. A pilot study was undertaken to analyze HAH and AMS cases in Indian lowlanders ascending to Leh city (3500 m) in western Himalayas.
A total number of 1228 Indian lowlanders, who ascended (fresh and re-inductees) by air and acclimatized, participated in this pilot study. The intensity of headache was assessed by the Visual Analogue Score. The parameters of HAH as per the International Classification of Headache Disorders-3 and 2018 Revised Lake Louise Questionnaire (LLQ) were used to differentiate HAH and AMS.
Out of 1228 cases, 78 (6.4%) cases had headache, of which 24 (1.95%) cases were HAH only, 40 (3.25%) cases AMS only and 14 (1.14%) cases were defined as both HAH and AMS. There was a significant difference in heart rate [F (2,51) = (4.756), P =0.01] between these groups. It also showed a difference in the correlation between the parameters within the groups. The Odd's Ratio of AMS in fresh and re-inductees was found to be 4.5 and for HAH it was 4.33.
The findings of this study suggest that LLQ has a tendency of overestimating AMS by including HAH cases. Furthermore differential parameters exhibit differences when AMS and HAH are considered separately. Re-inductees showed a lower incidence of HAH and AMS.
在海拔升高到高海拔地区时，高原性头痛（HAH）和急性高原病（AMS）在低地居民中很常见，且常被混淆。本研究旨在分析进入喜马拉雅山西部列城（海拔 3500 米）的印度低地居民中 HAH 和 AMS 病例。
共有 1228 名印度低地居民通过航空和适应的方式上升（新鲜和再诱导者），参与了这项初步研究。头痛的强度通过视觉模拟评分进行评估。使用国际头痛疾病分类第 3 版（ICHD-3）和 2018 年修订的路易斯湖问卷（LLQ）的 HAH 参数来区分 HAH 和 AMS。
在 1228 例中，78 例（6.4%）有头痛，其中 24 例（1.95%）仅有 HAH，40 例（3.25%）仅有 AMS，14 例（1.14%）被定义为 HAH 和 AMS 均有。组间心率存在显著差异[F（2,51）=（4.756），P=0.01]。这也表明组内各参数之间的相关性存在差异。新鲜和再诱导者的 AMS 的优势比为 4.5，HAH 为 4.33。
本研究结果表明，LLQ 在纳入 HAH 病例时可能高估了 AMS。此外，当分别考虑 AMS 和 HAH 时，差异参数表现出差异。再诱导者 HAH 和 AMS 的发病率较低。
