Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
J Hosp Infect. 2010 Nov;76(3):211-4. doi: 10.1016/j.jhin.2010.07.011.
Staphylococcus aureus is the major cause of surgical site infections, and meticillin-resistant S. aureus (MRSA) is increasingly accounting for infections worldwide. Preventing surgical site infections by screening and decolonising positive patients reduces the number of infections, but does not completely eradicate the risk. A balance between prevention, costs and the chance of mupirocin-resistant S. aureus needs to be evaluated and decolonisation strategies optimised. It is essential to know the site of S. aureus during colonisation. In this study, for the first time the exact location of S. aureus in the human nose was determined using a histological approach. We showed the presence of S. aureus in the cornified layer of squamous epithelium, associated keratin and mucous debris and within hair follicles in the vestibulum nasi. The presence of S. aureus in hair follicles suggests that this could be the niche from which relapses occur after decolonisation. Decolonisation strategies might have to be reconsidered.
金黄色葡萄球菌是手术部位感染的主要原因，耐甲氧西林金黄色葡萄球菌（MRSA）在全球范围内导致的感染越来越多。通过筛查和去定植阳性患者来预防手术部位感染可以减少感染数量，但并不能完全消除风险。需要评估预防、成本和耐莫匹罗星金黄色葡萄球菌的机会之间的平衡，并优化去定植策略。了解定植期间金黄色葡萄球菌的位置至关重要。在这项研究中，我们首次使用组织学方法确定了金黄色葡萄球菌在人鼻腔的确切位置。我们发现金黄色葡萄球菌存在于鳞状上皮的角化层、角蛋白和黏液碎屑以及前庭的毛囊中。金黄色葡萄球菌存在于毛囊中表明，这可能是去定植后复发的部位。去定植策略可能需要重新考虑。
