Alessandrini Giuseppe, Mercuri Santo R, Martella Alessandro, Ferrara Francesca, Simonetti Vito, Trifirò Caterina, Emanuele Enzo
Dermatology and Venereology Private Practice, Gallipoli, Lecce, Italy.
Unit of Dermatology, IRCCS San Raffaele Hospital, Milan, Italy.
Postepy Dermatol Alergol. 2023 Feb;40(1):115-118. doi: 10.5114/ada.2022.124108. Epub 2023 Jan 13.
Patients with mild-to-moderate acne are frequently colonized by on their skin, which alters microenvironmental skin conditions and exacerbates disease symptoms. Bacteriocins produced by may act as antimicrobial peptides against Gram-positive bacteria.
To investigate whether topical application of bacteriocins from could serve as a potential strategy for promoting decolonization from acneic skin.
The research product was a cream formulation containing 1% bacteriocins from . First, we conducted a 60-day pilot study on the effect of topically applied bacteriocins from on the absolute abundance of in 12 patients with mild-to-moderate acne. Second, we designed an 8-week, uncontrolled, open-label, multicentre clinical study to investigate whether the topical application of bacteriocins from reduces the number of inflammatory and non-inflammatory lesions, as well as Global Acne Grading Scale (GAGS) scores, in 373 patients with mild-to-moderate acne.
At the microbiological level, quantitative PCR showed a decrease in the absolute abundance of in acne areas after topical application of the research product for 60 days (-38%, < 0.001). In the clinical study, the number of inflammatory and non-inflammatory lesions was found to decrease at 8 weeks by 59% ( < 0.001) and 58% ( < 0.001), respectively, compared with baseline. A 56% decrease was observed for GAGS scores.
Topical bacteriocins from can promote decolonization in acneic skin, ultimately improving the clinical appearance of mild-to-moderate acne.
轻至中度痤疮患者的皮肤常常被[某种细菌]定植，这会改变皮肤微环境并加重疾病症状。[某种细菌]产生的细菌素可能作为抗革兰氏阳性菌的抗菌肽。
研究局部应用[某种细菌]产生的细菌素是否可作为促进痤疮皮肤[某种细菌]去定植的潜在策略。
研究产品为含1%[某种细菌]细菌素的乳膏制剂。首先，我们对12例轻至中度痤疮患者进行了一项为期60天的初步研究，观察局部应用[某种细菌]细菌素对[某种细菌]绝对丰度的影响。其次，我们设计了一项为期8周的非对照、开放标签、多中心临床研究，以调查局部应用[某种细菌]细菌素是否能减少373例轻至中度痤疮患者的炎性和非炎性皮损数量以及全球痤疮分级量表（GAGS）评分。
在微生物学水平上，定量PCR显示局部应用研究产品60天后，痤疮部位[某种细菌]的绝对丰度下降（-38%，P<0.001）。在临床研究中，与基线相比，8周时炎性和非炎性皮损数量分别减少了59%（P<0.001）和58%（P<0.001）。GAGS评分下降了56%。
局部应用[某种细菌]产生的细菌素可促进痤疮皮肤的[某种细菌]去定植，最终改善轻至中度痤疮的临床表现。
