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人参皂苷 Rb1 的碳量子点在脑出血小鼠模型中的应用。

Carbon quantum dots of ginsenoside Rb1 for application in a mouse model of intracerebral Hemorrhage.

机构信息

Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.

Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi, 330006, China.

出版信息

J Nanobiotechnology. 2024 Mar 22;22(1):125. doi: 10.1186/s12951-024-02368-w.

DOI:10.1186/s12951-024-02368-w
PMID:38520022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10958843/
Abstract

After intracerebral hemorrhage (ICH) occurs, the overproduction of reactive oxygen species (ROS) and iron ion overload are the leading causes of secondary damage. Removing excess iron ions and ROS in the meningeal system can effectively alleviate the secondary damage after ICH. This study synthesized ginsenoside Rb1 carbon quantum dots (RBCQDs) using ginsenoside Rb1 and ethylenediamine via a hydrothermal method. RBCQDs exhibit potent capabilities in scavenging ABTS + free radicals and iron ions in solution. After intrathecal injection, the distribution of RBCQDs is predominantly localized in the subarachnoid space. RBCQDs can eliminate ROS and chelate iron ions within the meningeal system. Treatment with RBCQDs significantly improves blood flow in the meningeal system, effectively protecting dying neurons, improving neurological function, and providing a new therapeutic approach for the clinical treatment of ICH.

摘要

脑出血（ICH）发生后，活性氧（ROS）的过度产生和铁离子过载是继发损伤的主要原因。去除脑膜系统中过多的铁离子和 ROS 可以有效减轻 ICH 后的继发损伤。本研究通过水热法以人参皂苷 Rb1 和乙二胺为原料合成了人参皂苷 Rb1 碳量子点（RBCQDs）。RBCQDs 在清除 ABTS+自由基和溶液中的铁离子方面表现出强大的能力。鞘内注射后，RBCQDs 的分布主要定位于蛛网膜下腔。RBCQDs 可以清除脑膜系统内的 ROS 和螯合铁离子。RBCQDs 治疗可显著改善脑膜系统的血流，有效保护濒死神经元，改善神经功能，为 ICH 的临床治疗提供了新的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0f4/10958843/d3ba33291185/12951_2024_2368_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0f4/10958843/e8bee5b0e5ad/12951_2024_2368_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0f4/10958843/0bbe3a767002/12951_2024_2368_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0f4/10958843/8ffef6eaf08e/12951_2024_2368_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0f4/10958843/4b8b1d81c472/12951_2024_2368_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0f4/10958843/75015b548c87/12951_2024_2368_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0f4/10958843/faae0ff860b9/12951_2024_2368_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0f4/10958843/d3ba33291185/12951_2024_2368_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0f4/10958843/e8bee5b0e5ad/12951_2024_2368_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0f4/10958843/f4d59a38300c/12951_2024_2368_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0f4/10958843/0bbe3a767002/12951_2024_2368_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0f4/10958843/8ffef6eaf08e/12951_2024_2368_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0f4/10958843/4b8b1d81c472/12951_2024_2368_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0f4/10958843/75015b548c87/12951_2024_2368_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0f4/10958843/faae0ff860b9/12951_2024_2368_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0f4/10958843/d3ba33291185/12951_2024_2368_Fig8_HTML.jpg

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