Peng Xiaoke, McClements David Julian, Liu Xuebo, Liu Fuguo
College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, China.
Department of Food Science, University of Massachusetts Amherst, Amherst, MA, USA.
Crit Rev Food Sci Nutr. 2025;65(12):2177-2198. doi: 10.1080/10408398.2024.2328184. Epub 2024 Mar 22.
(-)-Epigallocatechin-3-gallate (EGCG) is a natural phenolic substance found in foods and beverages (especially tea) that exhibits a broad spectrum of biological activities, including antioxidant, antimicrobial, anti-obesity, anti-inflammatory, and anti-cancer properties. Its potential in cardiovascular and brain health has garnered significant attention. However, its clinical application remains limited due to its poor physicochemical stability and low oral bioavailability. Nanotechnology can be used to improve the stability, efficacy, and pharmacokinetic profile of EGCG by encapsulating it within nanoparticles. This article reviews the interactions of EGCG with various compounds, the synthesis of EGCG-based nanoparticles, the functional attributes of these nanoparticles, and their prospective applications in drug delivery, diagnosis, and therapy. The potential application of nanoencapsulated EGCG in functional foods and beverages is also emphasized. Top-down and bottom-up approaches can be used to construct EGCG-based nanoparticles. EGCG-based nanoparticles exhibit enhanced stability and bioavailability compared to free EGCG, making them promising candidates for biomedical and food applications. Notably, the non-covalent and covalent interactions of EGCG with other substances significantly contribute to the improved properties of these nanoparticles. EGCG-based nanoparticles appear to have a wide range of applications in different industries, but further research is required to enhance their efficacy and ensure their safety.
（-）-表没食子儿茶素-3-没食子酸酯（EGCG）是一种存在于食品和饮料（尤其是茶）中的天然酚类物质，具有广泛的生物活性，包括抗氧化、抗菌、抗肥胖、抗炎和抗癌特性。它在心血管和大脑健康方面的潜力已引起广泛关注。然而，由于其物理化学稳定性差和口服生物利用度低，其临床应用仍然有限。纳米技术可通过将EGCG包裹在纳米颗粒中来提高其稳定性、功效和药代动力学特性。本文综述了EGCG与各种化合物的相互作用、基于EGCG的纳米颗粒的合成、这些纳米颗粒的功能属性及其在药物递送、诊断和治疗中的潜在应用。还强调了纳米包封EGCG在功能性食品和饮料中的潜在应用。自上而下和自下而上的方法可用于构建基于EGCG的纳米颗粒。与游离EGCG相比，基于EGCG的纳米颗粒具有更高的稳定性和生物利用度，使其成为生物医学和食品应用的有前途的候选者。值得注意的是，EGCG与其他物质的非共价和共价相互作用显著有助于改善这些纳米颗粒的性能。基于EGCG的纳米颗粒似乎在不同行业有广泛的应用，但需要进一步研究以提高其疗效并确保其安全性。
