Lachmansingh David Antoine, Valderrama Benjamin, Bastiaanssen Thomaz, Cryan John, Clarke Gerard, Lavelle Aonghus
Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, County Cork, Ireland.
APC Microbiome Ireland, University College Cork, Cork, County Cork, Ireland.
HRB Open Res. 2024 Feb 26;6:62. doi: 10.12688/hrbopenres.13794.2. eCollection 2023.
The gut microbiota has been extensively implicated in health and disease. The functional outputs of the gut microbiota, such as microbial metabolites, are considered particularly important in this regard. Significant associations exist between alterations in the relative abundance of specific microbial taxa and mental health disorders. Dietary fiber has the potential to alter gut microbiota composition and function, modifying bacterial enzymatic function and the production of metabolites. As many taxa of microorganisms have enzymes capable of producing or degrading neurochemicals i.e. neuroactive gut brain modules, new predictive tools can be applied to existing datasets such as those harvested from dietary fiber interventions. We endeavor to perform a systematic review in order to identify studies reporting compositional gut microbiota alterations after interventions with dietary fiber in healthy individuals. We aim to also extract from the selected studies publicly available microbial genomic sequence datasets for reanalysis with a consistent bioinformatics pipeline, with the ultimate intention of identifying altered gut brain modules following dietary fiber interventions.
Interventional trials and randomized controlled studies that are originally published, including cross-over and non-crossover design and involving healthy adult humans will be included. A systematic search of PubMed/MEDLINE and EMBASE, two electronic databases, will be completed.
Various types of dietary fiber have an impact on the gut microbiota composition, with some promoting the growth of particular taxa while others are reduced in relative abundance. Our search focuses on the impact of this food component on the microbiota of healthy individuals. Compositional gut microbial changes have been reported and our review will compile and update these observations after reanalysis of their datasets with a consistent bioinformatic pipeline. From this it may be possible to predict more detailed functional consequences in terms of neuroactive gut brain modules, of the compositional alterations in gut microbial taxa.
肠道微生物群与健康和疾病密切相关。在这方面，肠道微生物群的功能输出，如微生物代谢产物，被认为尤为重要。特定微生物类群相对丰度的改变与心理健康障碍之间存在显著关联。膳食纤维有可能改变肠道微生物群的组成和功能，改变细菌的酶功能和代谢产物的产生。由于许多微生物类群具有能够产生或降解神经化学物质（即神经活性肠脑模块）的酶，新的预测工具可应用于现有数据集，如从膳食纤维干预中收集的数据集。我们致力于进行一项系统综述，以识别报告健康个体膳食纤维干预后肠道微生物群组成变化的研究。我们还旨在从选定的研究中提取公开可用的微生物基因组序列数据集，用一致的生物信息学管道进行重新分析，最终目的是识别膳食纤维干预后改变的肠脑模块。
将纳入最初发表的干预试验和随机对照研究，包括交叉设计和非交叉设计，且涉及健康成年人。将完成对两个电子数据库PubMed/MEDLINE和EMBASE的系统检索。
不同类型的膳食纤维对肠道微生物群组成有影响，一些促进特定类群的生长，而另一些的相对丰度则降低。我们的检索重点是这种食物成分对健康个体微生物群的影响。已经报道了肠道微生物组成的变化，我们的综述将在用一致的生物信息学管道重新分析其数据集后，汇编并更新这些观察结果。由此，有可能预测肠道微生物类群组成改变在神经活性肠脑模块方面更详细的功能后果。
