Onishi Yasuyuki, Shimizu Hironori, Koyasu Sho, Taura Daisuke, Takahashi Ayako, Uza Norimitsu, Isoda Hiroyoshi, Nakamoto Yuji
Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto, JPN.
Von Hippel-Lindau Disease (VHL) Center, Kyoto University Hospital, Kyoto, JPN.
Cureus. 2024 Feb 23;16(2):e54781. doi: 10.7759/cureus.54781. eCollection 2024 Feb.
Pancreatic cysts are frequently observed in patients with von Hippel-Lindau disease (VHL), and they are considered clinically not important. This study aimed to evaluate the association between pancreatic cysts and diabetes mellitus (DM) in patients with VHL.
Among patients who were on a patient list at the VHL Center at Kyoto University Hospital as of December 2022, those who had undergone an upper abdominal magnetic resonance imaging study after 2010 were retrospectively evaluated. The presence or absence of DM and high glycated hemoglobin (HbA1c) levels (>6.0%) were assessed. Patients were divided into two groups: those with DM or high HbA1c levels, and those without DM or high HbA1c levels. The area of the whole pancreas, including the pancreatic cysts and tumors, the area of the pancreatic cysts, and the percentage of pancreatic cysts, calculated by dividing the area of pancreatic cysts by the area of the whole pancreas, were measured on T2-weighted magnetic resonance images and compared between the two groups.
Thirty-six patients with VHL, comprising 22 men and 14 women, with a mean age of 36.4 years (range, 11-79 years), were identified. Seven patients had DM, and two additional patients had high HbA1c levels. The area of the pancreatic cysts (p = 0.0013) was significantly larger and the percentage of the pancreatic cysts (p = 0.0016) was significantly higher in patients with DM or high HbA1c levels (n = 9) than in patients without DM or high HbA1c levels (n = 27); however, the difference in the area of the whole pancreas was not significant (p = 0.068).
Our findings suggest that patients with VHL who have a large area covered by pancreatic cysts are more likely to have DM than those without.
胰腺囊肿在冯·希佩尔-林道病（VHL）患者中经常被观察到，并且在临床上被认为不重要。本研究旨在评估VHL患者中胰腺囊肿与糖尿病（DM）之间的关联。
在截至2022年12月在京都大学医院VHL中心患者名单上的患者中，对那些在2010年后接受过上腹部磁共振成像检查的患者进行回顾性评估。评估DM的存在与否以及高糖化血红蛋白（HbA1c）水平（>6.0%）。患者被分为两组：患有DM或高HbA1c水平的患者，以及没有DM或高HbA1c水平的患者。在T2加权磁共振图像上测量整个胰腺的面积，包括胰腺囊肿和肿瘤、胰腺囊肿的面积以及通过将胰腺囊肿面积除以整个胰腺面积计算出的胰腺囊肿百分比，并在两组之间进行比较。
确定了36例VHL患者，包括22名男性和14名女性，平均年龄为36.4岁（范围为11 - 79岁）。7例患者患有DM，另外2例患者HbA1c水平高。患有DM或高HbA1c水平的患者（n = 9）的胰腺囊肿面积（p = 0.0013）显著更大，胰腺囊肿百分比（p = 0.0016）显著更高，高于没有DM或高HbA1c水平的患者（n = 27）；然而，整个胰腺面积的差异不显著（p = 0.068）。
我们的研究结果表明，胰腺囊肿覆盖面积大的VHL患者比没有这种情况的患者更有可能患有DM。
