Department of Pharmaceutical Sciences. University of Vila Velha - UVV. Vila Velha, Espírito Santo, Brazil.
JBRA Assist Reprod. 2024 Jun 1;28(2):341-348. doi: 10.5935/1518-0557.20240013.
Infertility is a widespread global issue that affects approximately 15% of sexually active and active couples, which contributes to about 50% of cases. Currently, the condition remains prevalent and often inadequately treated. This systematic review aims to evaluate existing studies investigating the effects of probiotic supplementation in men. A comprehensive search was conducted across major databases, including PubMed, Cochrane, Science Direct, and Scielo, using relevant keywords such as 'probiotic' OR 'Lactobacillus' OR 'Bifidobacterium' AND 'Male infertility' OR 'male fertility' OR 'sperm quality' OR 'sperm motility' OR 'oligoasthenoteratozoospermia' and their Portuguese equivalents. Four randomized clinical studies met the inclusion criteria, focusing on men diagnosed with idiopathic male infertility (oligozoospermia, teratozoospermia, and asthenozoospermia). The findings revealed that probiotic administration exhibited promising antioxidant properties by combating reactive oxygen species (ROS), consequently protecting sperm DNA from damage that correlates with declining sperm quality. Significant improvements were observed across all sperm parameters, with notable enhancement in motility. Consequently, probiotic supplementation emerges as a potential therapeutic alternative for men diagnosed with idiopathic infertility, demonstrating positive effects on sperm quality.
不孕不育是一个全球性的普遍问题，大约影响了 15%的有生育能力且活跃的夫妇，其中约 50%的病例与不孕不育有关。目前，这种情况仍然普遍存在，且往往得不到充分治疗。本系统综述旨在评估现有研究，以调查益生菌补充剂对男性的影响。我们在主要数据库中进行了全面搜索，包括 PubMed、Cochrane、Science Direct 和 Scielo，并使用了相关关键词，如“益生菌”或“乳酸菌”或“双歧杆菌”以及“男性不育”或“男性生育力”或“精子质量”或“精子活力”或“少精弱精症”及其葡萄牙语等效词。四项符合纳入标准的随机临床试验专注于诊断为特发性男性不育症（少精症、弱精症和畸形精子症）的男性。研究结果表明，益生菌给药通过对抗活性氧（ROS）表现出有希望的抗氧化特性，从而保护精子 DNA 免受与精子质量下降相关的损伤。所有精子参数均观察到显著改善，活力显著增强。因此，益生菌补充剂成为诊断为特发性不育症的男性的一种潜在治疗选择，对精子质量具有积极影响。
