Omore Richard, Awuor Alex O, Ogwel Billy, Okonji Caleb, Sonye Catherine, Oreso Caren, Akelo Victor, Amollo Manase, Ogudi Isaiah, Anyango Raphael O, Audi Marjorie, Apondi Evans, Riziki Laura, Ambila Lilian, Dilruba Nasrin, Muok Erick, Munga Stephen, Ochieng John B, Kotloff Karen L
Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Department of Clinical Medicine, Liverpool School of Tropical Medicine, Kisumu, Kenya.
Open Forum Infect Dis. 2024 Mar 25;11(Suppl 1):S91-S100. doi: 10.1093/ofid/ofad654. eCollection 2024 Mar.
Although is an important cause of diarrhea in Kenyan children, robust research platforms capable of conducting incidence-based estimates and eventual targeted clinical trials are needed to improve -related outcomes in children. Here, we describe characteristics of a disease surveillance platform whose goal is to support incidence and consequences of diarrhea as part of multicounty surveillance aimed at preparing sites and assembling expertise for future vaccine trials.
We mobilized our preexisting expertise in shigellosis, vaccinology, and diarrheal disease epidemiology, which we combined with our experience conducting population-based sampling, clinical trials with high (97%-98%) retention rates, and healthcare utilization surveys. We leveraged our established demographic surveillance system (DSS), our network of healthcare centers serving the DSS, and our laboratory facilities with staff experienced in performing microbiologic and molecular diagnostics to identify enteric infections. We joined these resources with an international network of sites with similar capabilities and infrastructure to form a cohesive scientific network, designated Enterics for Global Health (EFGH), with the aim of expanding and updating our knowledge of the epidemiology and adverse consequences of shigellosis and enriching local research and career development priorities.
surveillance data from this platform could help inform vaccine trials.
尽管[疾病名称]是肯尼亚儿童腹泻的一个重要病因，但需要强大的研究平台来进行基于发病率的[疾病名称]估计并开展最终的靶向临床试验，以改善儿童与[疾病名称]相关的结局。在此，我们描述了一个疾病监测平台的特征，其目标是支持[疾病名称]腹泻的发病率及后果研究，作为多县监测的一部分，旨在为未来的[疾病名称]疫苗试验准备场地并汇聚专业知识。
我们调动了在志贺菌病、疫苗学和腹泻病流行病学方面已有的专业知识，并将其与我们在进行基于人群的抽样、保留率高（97%-98%）的临床试验以及医疗保健利用调查方面的经验相结合。我们利用了已建立的人口监测系统（DSS）、服务于DSS的医疗中心网络以及拥有进行微生物和分子诊断经验丰富的工作人员的实验室设施，以识别肠道感染。我们将这些资源与具有类似能力和基础设施的国际站点网络相结合，形成了一个有凝聚力的科学网络，即全球健康肠道疾病研究网络（EFGH），目的是扩展和更新我们对志贺菌病流行病学及不良后果的认识，并丰富当地的研究和职业发展重点。
该平台的[疾病名称]监测数据有助于为[疾病名称]疫苗试验提供信息。
