Ayub Aaqib, Cheong Yuen Ki, Castro Jesus Calvo, Cumberlege Oliver, Chrysanthou Andreas
School of Physics, Engineering and Computer Science, University of Hertfordshire, Hatfield AL10 9AB, UK.
School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK.
Bioengineering (Basel). 2024 Feb 22;11(3):205. doi: 10.3390/bioengineering11030205.
Disinfection of nosocomial pathogens in hospitals is crucial to combat healthcare-acquired infections, which can be acquired by patients, visitors and healthcare workers. However, the presence of a wide range of pathogens and biofilms, combined with the indiscriminate use of antibiotics, presents infection control teams in healthcare facilities with ongoing challenges in the selection of biocides and application methods. This necessitates the development of biocides and innovative disinfection methods that overcome the shortcomings of conventional methods. This comprehensive review finds the use of hydrogen peroxide vapour to be a superior alternative to conventional methods. Motivated by observations in previous studies, herein, we provide a comprehensive overview on the utilisation of hydrogen peroxide vapour as a superior high-level disinfection alternative in hospital settings. This review finds hydrogen peroxide vapour to be very close to an ideal disinfectant due to its proven efficacy against a wide range of microorganisms, safety to use, lack of toxicity concerns and good material compatibility. The superiority of hydrogen peroxide vapour was recently demonstrated in the case of decontamination of N95/FFP2 masks for reuse to address the critical shortage caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the COVID-19 pandemic. Despite the significant number of studies demonstrating antimicrobial activity, there remains a need to critically understand the mechanism of action by performing studies that simultaneously measure damage to all bacterial cell components and assess the correlation of this damage with a reduction in viable cell count. This can lead to improvement in antimicrobial efficacy and foster the development of superior approaches.
医院内医院病原体的消毒对于对抗医疗保健相关感染至关重要，这些感染可由患者、访客和医护人员获得。然而，多种病原体和生物膜的存在，再加上抗生素的滥用，给医疗机构的感染控制团队在选择杀菌剂和应用方法方面带来了持续的挑战。这就需要开发克服传统方法缺点的杀菌剂和创新消毒方法。这篇综述发现过氧化氢蒸汽的使用是传统方法的一种更优替代方案。基于先前研究中的观察结果，在此，我们全面概述了过氧化氢蒸汽作为医院环境中一种更优的高水平消毒替代方法的应用。这篇综述发现过氧化氢蒸汽非常接近理想的消毒剂，因为它对多种微生物已证实的有效性、使用安全性、无毒性问题以及良好的材料兼容性。最近，在对N95/FFP2口罩进行消毒以重复使用以应对2019年冠状病毒病（COVID - 19）大流行期间严重急性呼吸综合征冠状病毒2（SARS-CoV-2）造成的严重短缺情况中，过氧化氢蒸汽的优越性得到了证明。尽管有大量研究证明了其抗菌活性，但仍需要通过同时测量对所有细菌细胞成分的损伤并评估这种损伤与活细胞数量减少之间的相关性来深入了解其作用机制。这可以提高抗菌效果并促进更优方法的开发。
