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基于分组超声图像数据训练的风险控制神经网络的脂肪肝分类。

Fatty liver classification via risk controlled neural networks trained on grouped ultrasound image data.

机构信息

Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.

出版信息

Sci Rep. 2024 Mar 28;14(1):7345. doi: 10.1038/s41598-024-57386-3.

DOI:10.1038/s41598-024-57386-3
PMID:38538649
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10973492/
Abstract

Ultrasound imaging is a widely used technique for fatty liver diagnosis as it is practically affordable and can be quickly deployed by using suitable devices. When it is applied to a patient, multiple images of the targeted tissues are produced. We propose a machine learning model for fatty liver diagnosis from multiple ultrasound images. The machine learning model extracts features of the ultrasound images by using a pre-trained image encoder. It further produces a summary embedding on these features by using a graph neural network. The summary embedding is used as input for a classifier on fatty liver diagnosis. We train the machine learning model on a ultrasound image dataset collected by Taiwan Biobank. We also carry out risk control on the machine learning model using conformal prediction. Under the risk control procedure, the classifier can improve the results with high probabilistic guarantees.

摘要

超声成像是一种广泛应用于脂肪肝诊断的技术,因为它在实际中具有成本效益,并且可以使用合适的设备快速部署。当应用于患者时,会生成多个目标组织的图像。我们提出了一种基于多幅超声图像的脂肪肝诊断的机器学习模型。该机器学习模型使用预训练的图像编码器从超声图像中提取特征。它进一步通过图神经网络对这些特征生成一个摘要嵌入。该摘要嵌入被用作脂肪肝诊断分类器的输入。我们在台湾生物银行收集的超声图像数据集上训练了机器学习模型。我们还使用一致性预测对机器学习模型进行风险控制。在风险控制过程中,分类器可以在具有高概率保证的情况下提高结果。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b5/10973492/8c7a88330512/41598_2024_57386_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b5/10973492/bfb4a312a2fa/41598_2024_57386_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b5/10973492/2479b12924fe/41598_2024_57386_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b5/10973492/61023c95d8f2/41598_2024_57386_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b5/10973492/5e89c33fba86/41598_2024_57386_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b5/10973492/871f2e65cb24/41598_2024_57386_Fig9_HTML.jpg

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本文引用的文献

1
Artificial Intelligence for Detecting and Quantifying Fatty Liver in Ultrasound Images: A Systematic Review.用于检测和量化超声图像中脂肪肝的人工智能:一项系统综述。
Bioengineering (Basel). 2022 Dec 1;9(12):748. doi: 10.3390/bioengineering9120748.
2
Deep Learning Techniques for Fatty Liver Using Multi-View Ultrasound Images Scanned by Different Scanners: Development and Validation Study.使用不同扫描仪扫描的多视图超声图像的深度学习技术在脂肪肝中的应用:开发与验证研究
JMIR Med Inform. 2021 Nov 18;9(11):e30066. doi: 10.2196/30066.
3
Cascaded Deep Learning Neural Network for Automated Liver Steatosis Diagnosis Using Ultrasound Images.
基于超声图像的级联深度学习神经网络用于自动化肝脂肪变性诊断。
Sensors (Basel). 2021 Aug 5;21(16):5304. doi: 10.3390/s21165304.
4
Deep learning for abdominal ultrasound: A computer-aided diagnostic system for the severity of fatty liver.深度学习在腹部超声中的应用:一种用于评估脂肪肝严重程度的计算机辅助诊断系统。
J Chin Med Assoc. 2021 Sep 1;84(9):842-850. doi: 10.1097/JCMA.0000000000000585.
5
Liver disease classification from ultrasound using multi-scale CNN.利用多尺度卷积神经网络进行超声肝脏疾病分类。
Int J Comput Assist Radiol Surg. 2021 Sep;16(9):1537-1548. doi: 10.1007/s11548-021-02414-0. Epub 2021 Jun 7.
6
Multi-Source Transfer Learning Via Multi-Kernel Support Vector Machine Plus for B-Mode Ultrasound-Based Computer-Aided Diagnosis of Liver Cancers.基于多模态超声的肝癌计算机辅助诊断中的多源迁移学习方法 **解析**:文章标题是一个复合句,“Multi-Source Transfer Learning Via Multi-Kernel Support Vector Machine Plus”是主语,“for B-Mode Ultrasound-Based Computer-Aided Diagnosis of Liver Cancers”是后置定语,修饰主语。因此,可将其翻译为“基于多模态超声的肝癌计算机辅助诊断中的多源迁移学习方法”。
IEEE J Biomed Health Inform. 2021 Oct;25(10):3874-3885. doi: 10.1109/JBHI.2021.3073812. Epub 2021 Oct 5.
7
Implementation of Combinational Deep Learning Algorithm for Non-alcoholic Fatty Liver Classification in Ultrasound Images.用于超声图像中非酒精性脂肪肝分类的组合深度学习算法的实现
J Biomed Phys Eng. 2021 Feb 1;11(1):73-84. doi: 10.31661/jbpe.v0i0.2009-1180. eCollection 2021 Feb.
8
Clinical Value of Information Entropy Compared with Deep Learning for Ultrasound Grading of Hepatic Steatosis.信息熵与深度学习在肝脂肪变性超声分级中的临床价值比较
Entropy (Basel). 2020 Sep 9;22(9):1006. doi: 10.3390/e22091006.
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Improving B-mode ultrasound diagnostic performance for focal liver lesions using deep learning: A multicentre study.利用深度学习提高局灶性肝病变的 B 型超声诊断性能:一项多中心研究。
EBioMedicine. 2020 Jun;56:102777. doi: 10.1016/j.ebiom.2020.102777. Epub 2020 Apr 28.
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Quantitative ultrasound approaches for diagnosis and monitoring hepatic steatosis in nonalcoholic fatty liver disease.用于非酒精性脂肪性肝病肝脂肪变性诊断和监测的定量超声方法
Theranostics. 2020 Mar 4;10(9):4277-4289. doi: 10.7150/thno.40249. eCollection 2020.