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探索基于环糊精的纳米海绵作为药物传递系统：理解影响药物装载和释放动力学的物理化学因素。

Exploring Cyclodextrin-Based Nanosponges as Drug Delivery Systems: Understanding the Physicochemical Factors Influencing Drug Loading and Release Kinetics.

机构信息

Doctoral School, Medical University of Warsaw, Żwirki i Wigury 81, 02-093 Warsaw, Poland.

Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.

出版信息

Int J Mol Sci. 2024 Mar 20;25(6):3527. doi: 10.3390/ijms25063527.

DOI:10.3390/ijms25063527
PMID:38542499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10971266/
Abstract

Cyclodextrin-based nanosponges (CDNSs) are complex macromolecular structures composed of individual cyclodextrins (CDs) and nanochannels created between cross-linked CD units and cross-linkers. Due to their unique structural and physicochemical properties, CDNSs can possess even more beneficial pharmaceutical features than single CDs. In this comprehensive review, various aspects related to CDNSs are summarized. Particular attention was paid to overviewing structural properties, methods of synthesis, and physicochemical analysis of CDNSs using various analytical methods, such as DLS, PXRD, TGA, DSC, FT-IR, NMR, and phase solubility studies. Also, due to the significant role of CDNSs in pharmaceutical research and industry, aspects such as drug loading, drug release studies, and kinetics profile evaluation of drug-CDNS complexes were carefully reviewed. The aim of this paper is to find the relationships between the physicochemical features and to identify crucial characteristics that are influential for using CDNSs as convenient drug delivery systems.

摘要

基于环糊精的纳米海绵（CDNSs）是由单个环糊精（CDs）和交联 CD 单元与交联剂之间形成的纳米通道组成的复杂大分子结构。由于其独特的结构和物理化学性质，CDNSs 比单个 CDs 具有更多有益的药物特性。在这篇全面的综述中，总结了与 CDNSs 相关的各个方面。特别关注了使用各种分析方法（如 DLS、PXRD、TGA、DSC、FT-IR、NMR 和相溶解度研究）综述 CDNSs 的结构特性、合成方法和物理化学分析。此外，由于 CDNSs 在药物研究和工业中的重要作用，还仔细审查了载药、药物释放研究以及药物-CDNS 配合物的动力学曲线评价等方面。本文的目的是找到物理化学性质之间的关系，并确定对 CDNSs 作为方便的药物传递系统的影响的关键特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/58c34fc9b9fe/ijms-25-03527-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/5518b0f4203c/ijms-25-03527-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/0e594f03d3bb/ijms-25-03527-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/e5e1017c66c3/ijms-25-03527-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/8dab416ef970/ijms-25-03527-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/2bf980ee66ce/ijms-25-03527-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/227d6d78416c/ijms-25-03527-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/22a8585b428d/ijms-25-03527-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/208cf0bb3650/ijms-25-03527-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/338f1a1ef516/ijms-25-03527-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/58c34fc9b9fe/ijms-25-03527-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/5518b0f4203c/ijms-25-03527-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/0e594f03d3bb/ijms-25-03527-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/e5e1017c66c3/ijms-25-03527-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/8dab416ef970/ijms-25-03527-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/2bf980ee66ce/ijms-25-03527-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/227d6d78416c/ijms-25-03527-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/22a8585b428d/ijms-25-03527-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/208cf0bb3650/ijms-25-03527-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/338f1a1ef516/ijms-25-03527-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1034/10971266/58c34fc9b9fe/ijms-25-03527-g010.jpg

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本文引用的文献

[1]
Cyclodextrins and Their Polymers Affect Human Serum Albumin's Interaction with Drugs Used in the Treatment of Pulmonary Infections.

Pharmaceutics. 2023-5-25

[2]
Development of Diphenyl carbonate-Crosslinked Cyclodextrin Based Nanosponges for Oral Delivery of Baricitinib: Formulation, Characterization and Pharmacokinetic Studies.

Int J Nanomedicine. 2023

[3]
Optimisation of a Greener-Approach for the Synthesis of Cyclodextrin-Based Nanosponges for the Solubility Enhancement of Domperidone, a BCS Class II Drug.

Pharmaceuticals (Basel). 2023-4-10

[4]
Formulation and evaluation of Piroxicam nanosponge for improved internal solubility and analgesic activity.

Drug Deliv. 2023-12

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Weak complexation of 5-fluorouracil with β-cyclodextrin, carbonate, and dianhydride crosslinked β-cyclodextrin: and studies.

Res Pharm Sci. 2022-7-14

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Versatile Applications of Nanosponges in Biomedical Field: A Glimpse on SARS-CoV-2 Management.

Bionanoscience. 2022

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Cyclodextrin-Based Nanosponges: Overview and Opportunities.

Front Chem. 2022-3-24

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The ascension of nanosponges as a drug delivery carrier: preparation, characterization, and applications.

J Mater Sci Mater Med. 2022-3-4

[9]
Recent Advances of Porous Materials Based on Cyclodextrin.

Macromol Rapid Commun. 2021-12

[10]
Solubility and dissolution rate enhancement of ibuprofen by cyclodextrin based carbonate nanosponges.

Pak J Pharm Sci. 2021-5

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