a Faculty of Pharmacy , Tabriz University of Medical Science , Tabriz , Iran.
b Student Research Committee , Tabriz University of Medical Science , Tabriz , Iran.
Expert Opin Drug Deliv. 2019 May;16(5):467-479. doi: 10.1080/17425247.2019.1591365. Epub 2019 May 14.
In recent years, new drug delivery systems have attempted to overcome the undesirable pharmacokinetic problems of various drugs. Among them, cyclodextrin nanosponges (CDNSs) attract great attention from researchers for solving major bioavailability problems such as inadequate solubility, poor dissolution rate, and the limited stability of some agents, as well as increasing their effectiveness and decreasing unwanted side effects. This novel system can also be prepared as different dosage forms.
This review will give an insight into the effects of CDNSs on the pharmacokinetic parameters and permeability of active agents. Different classes of drugs delivered by this system are mentioned and we designate which CD is used most widely in their production process. We also inform why this carrier can be introduced as a versatile carrying system in pharmaceutical fields. Registered patents about this novel system in various fields are also mentioned.
The readers will be informed on CDNSs as a novel carrier especially for the delivery of drugs. Versatile characteristics and applications of them can also be known by this review. Finally, CDNSs may be introduced as a remarkable vehicle in the pharmaceutical market in coming years.
近年来，新的药物传递系统试图克服各种药物不良的药代动力学问题。其中，环糊精纳米海绵（CDNSs）引起了研究人员的极大关注，可用于解决一些药物的主要生物利用度问题，如溶解度不足、溶解速率低、某些药物的稳定性有限，以及提高其有效性和降低不良反应。该新型系统还可以制备成不同的剂型。
本文综述了 CDNS 对药物活性成分的药代动力学参数和渗透性的影响。本文提到了通过该系统递送的不同类别药物，并指出在其生产过程中最广泛使用的 CD。我们还介绍了为什么该载体可以作为一种多功能的载药系统引入制药领域。本文还提到了该新型系统在各个领域的已注册专利。
读者将了解 CDNS 作为一种新型载体，特别是用于药物传递。通过这篇综述还可以了解它们的多功能特性和应用。最后，CDNSs 可能会在未来几年作为一种显著的药物载体进入制药市场。
