Jandang Wipanan, Ampasavate Chadarat, Kiattisin Kanokwan
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Center for Excellent in Pharmaceutical Nanotechnology, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Pharmaceutics. 2024 Mar 17;16(3):412. doi: 10.3390/pharmaceutics16030412.
Capsaicin and curcumin, the active components of chili and turmeric, are prone to instability when exposed to light. Therefore, this research aimed to enhance the photostability of both extracts via the use of antioxidants, natural sunscreen, and nanostructured lipid carriers (NLCs). NLCs were chosen for this this study due to their advantages in terms of stability, drug loading capacity, occlusive effect, skin penetration, and controlled release. The photostability of each extract and extracts mixed with antioxidants, including grape seed extract, tea extract, and chlorogenic acid, were determined. Chlorogenic acid can enhance the photostability of capsaicin from 6.79 h to 16.50 h, while the photostability of curcumin increased from 9.63 h to 19.25 h. In addition, the use of natural sunscreen (sunflower oil) also increased the photostability of capsaicin and curcumin. The mixed extracts were then loaded into NLCs. The particle size of the formulation was 153.73 nm with a PDI value of 0.25. It exhibited high entrapment efficiency (more than 95%). In addition, it effectively reduced the decomposition of capsaicin and curcumin. Importantly, the natural stabilizers chosen for NLC fabrication significantly improved the photostability of curcumin and capsaicin by 600% and 567% compared to the unstabilized counterparts. This improvement contributes to the sustainability and bioavailability of these compounds in both cosmeceutical and pharmaceutical products.
辣椒素和姜黄素分别是辣椒和姜黄中的活性成分，在光照下容易不稳定。因此，本研究旨在通过使用抗氧化剂、天然防晒剂和纳米结构脂质载体（NLC）来提高这两种提取物的光稳定性。本研究选择NLC是因其在稳定性、载药量、封闭作用、皮肤渗透性和控释方面具有优势。测定了每种提取物以及与抗氧化剂（包括葡萄籽提取物、茶提取物和绿原酸）混合后的提取物的光稳定性。绿原酸可将辣椒素的光稳定性从6.79小时提高到16.50小时，而姜黄素的光稳定性则从9.63小时提高到19.25小时。此外，使用天然防晒剂（向日葵油）也提高了辣椒素和姜黄素的光稳定性。然后将混合提取物载入NLC中。该制剂的粒径为153.73 nm，多分散指数（PDI）值为0.25。其包封率很高（超过95%）。此外，它有效减少了辣椒素和姜黄素的分解。重要的是，与未稳定化的对应物相比，用于制备NLC的天然稳定剂使姜黄素和辣椒素的光稳定性显著提高了600%和567%。这一改进有助于这些化合物在化妆品和药品中的可持续性和生物利用度。
