Youn Moon Yeon, Cho Jin-Ju, Hong Seong Jun, Jo Seong Min, Jeong Hyangyeon, Yoon Sojeong, Ban Younglan, Park Hyeonjin, Kim Jae Kyeom, Kim Young Jun, Shin Eui-Cheol
Department of GreenBio Science/Food Science and Technology, Gyeongsang National University, Jinju 52725, Republic of Korea.
Nonghyup Food Research Institute, Suwon 16506, Republic of Korea.
Food Chem X. 2024 Mar 19;22:101304. doi: 10.1016/j.fochx.2024.101304. eCollection 2024 Jun 30.
This study evaluated the effects of inhaling var. (OFA) extracts in Sprague-Dawley (SD) rats experiencing chronic stress. Rats were exposed to restraint stress or circadian disruption and were inhaled either distilled water or OFA extracts. Electronic nose (E-nose) analysis identified 35 volatile aromatic compounds (VACs) in OFA extracts. Chronic stress led to a decrease in body weight initially, serotonin concentration, and the weights of the liver, kidneys, and fat pads. Additionally, circadian disruption increased melatonin levels and decreased cholesterol concentrations. Inhalation of OFA increased dietary intake during the early phase and restored the tissue weights that have changed by chronic stress. Furthermore, it led to an increase in melatonin levels and changes in cholesterol levels. Taken together, our results indicate that OFA inhalation improves physiological changes caused by chronic stress through regulating dietary intake, restoring tissue weights, and modulating hormone and cholesterol levels.
本研究评估了吸入花椒提取物对经历慢性应激的斯普拉格-道利（SD）大鼠的影响。大鼠被施加束缚应激或昼夜节律紊乱，然后吸入蒸馏水或花椒提取物。电子鼻分析鉴定出花椒提取物中的35种挥发性芳香化合物（VACs）。慢性应激最初导致体重、血清素浓度以及肝脏、肾脏和脂肪垫重量下降。此外，昼夜节律紊乱会增加褪黑素水平并降低胆固醇浓度。吸入花椒提取物在早期增加了饮食摄入量，并恢复了因慢性应激而改变的组织重量。此外，它还导致褪黑素水平升高和胆固醇水平变化。综上所述，我们的结果表明，吸入花椒提取物可通过调节饮食摄入、恢复组织重量以及调节激素和胆固醇水平来改善慢性应激引起的生理变化。
