Tsujita Maki, Melchior John T, Yokoyama Shinji
Department of Biochemistry, Nagoya City University Graduate School of Medical Sciences, Japan (M.T.).
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington (J.T.M.).
Arterioscler Thromb Vasc Biol. 2024 May;44(5):1042-1052. doi: 10.1161/ATVBAHA.123.318284. Epub 2024 Mar 28.
The brain is the most lipid-rich organ in the body, and the intricate interplay between lipid metabolism and pathologies associated with neurodegenerative disorders is being increasingly recognized. The brain is bathed in cerebrospinal fluid (CSF), which, like plasma, contains lipid-protein complexes called lipoproteins that are responsible for extracellular lipid transport. Multiple CSF lipoprotein populations exist, some of which are produced de novo in the central nervous system and others that appear to be generated from protein constituents that are produced in the periphery. These CSF lipoproteins are thought to play key roles in maintaining lipid homeostasis in the central nervous system, while little else is known due to their limited accessibility and their low abundance in CSF. Recent work has provided new insights into the compositional complexity of CSF lipoprotein families and their metabolism in cerebral circulation. The purpose of this review is to summarize our current state of knowledge on the composition, origin, and metabolism of CSF lipoproteins.
大脑是人体中脂质含量最丰富的器官，脂质代谢与神经退行性疾病相关病理学之间复杂的相互作用正日益受到认可。大脑浸泡在脑脊液（CSF）中，脑脊液与血浆一样，含有称为脂蛋白的脂质 - 蛋白质复合物，这些复合物负责细胞外脂质运输。存在多种脑脊液脂蛋白群体，其中一些是在中枢神经系统中从头合成的，而其他一些似乎是由外周产生的蛋白质成分生成的。这些脑脊液脂蛋白被认为在维持中枢神经系统的脂质稳态中起关键作用，但由于它们在脑脊液中的可及性有限且含量低，人们对它们的了解很少。最近的研究工作为脑脊液脂蛋白家族的组成复杂性及其在脑循环中的代谢提供了新的见解。本综述的目的是总结我们目前关于脑脊液脂蛋白的组成、起源和代谢的知识状态。
