State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Key Laboratory of Biopharmaceutical Preparation and Delivery, Chinese Academy of Sciences, Beijing, 100190, China.
Adv Mater. 2024 Jun;36(26):e2313955. doi: 10.1002/adma.202313955. Epub 2024 Apr 12.
Leukemia is a widespread hematological malignancy characterized by an elevated white blood cell count in both the blood and the bone marrow. Despite notable advancements in leukemia intervention in the clinic, a large proportion of patients, especially acute leukemia patients, fail to achieve long-term remission or complete remission following treatment. Therefore, leukemia therapy necessitates optimization to meet the treatment requirements. In recent years, a multitude of materials have undergone rigorous study to serve as delivery vectors or direct intervention agents to bolster the effectiveness of leukemia therapy. These materials include liposomes, protein-based materials, polymeric materials, cell-derived materials, and inorganic materials. They possess unique characteristics and are applied in a broad array of therapeutic modalities, including chemotherapy, gene therapy, immunotherapy, radiotherapy, hematopoietic stem cell transplantation, and other evolving treatments. Here, an overview of these materials is presented, describing their physicochemical properties, their role in leukemia treatment, and the challenges they face in the context of clinical translation. This review inspires researchers to further develop various materials that can be used to augment the efficacy of multiple therapeutic modalities for novel applications in leukemia treatment.
白血病是一种广泛存在的血液恶性肿瘤，其特征是血液和骨髓中的白细胞计数升高。尽管在临床中白血病干预取得了显著进展，但很大一部分患者，尤其是急性白血病患者，在治疗后无法实现长期缓解或完全缓解。因此，白血病的治疗需要优化以满足治疗需求。近年来，大量材料经过严格研究，被用作递送载体或直接干预剂，以提高白血病治疗的效果。这些材料包括脂质体、基于蛋白质的材料、聚合物材料、细胞衍生材料和无机材料。它们具有独特的特性，并应用于广泛的治疗方式，包括化疗、基因治疗、免疫治疗、放射治疗、造血干细胞移植和其他不断发展的治疗方法。在这里，对这些材料进行了概述，描述了它们的物理化学性质、在白血病治疗中的作用以及在临床转化中面临的挑战。这篇综述激发了研究人员进一步开发各种材料的兴趣，这些材料可用于增强多种治疗方式的疗效，从而为白血病治疗的新应用提供新的机会。
