University Hospital Merkur, Department of Haematology, Zagreb, Croatia.
University Hospital Dubrava, Department of Endocrinology, Zagreb, Croatia.
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):24-31. doi: 10.2478/aiht-2024-75-3793. eCollection 2024 Mar 1.
As novel substances, short time windows, and limits of detection increasingly challenge direct methods of doping detection in sports, indirect tools inevitably take a greater role in the fight against it. One such tool is the athlete biological passport (ABP) - a longitudinal profiling of the measured haematological and biochemical biomarkers, combined with calculated scores, against the background of epidemiological data crucial for doping detection. In both of its modules, haematological and steroidal, ABP parameters are analysed with the Bayesian adaptive model, which individualises reference and cut-off values to improve its sensitivity. It takes into account the confounding factors with proven and potential influence on the biomarkers, such as race and altitude exposure. The ABP has already changed the fight against doping, but its importance will further grow with the new modules (e.g., endocrinological), parameters (e.g., plasma volume-independent parameters), and complementing indirect methods (e.g., transcriptomic).
作为新型物质，检测窗口期较短且检测极限不断增加，这使得在运动中直接检测兴奋剂的方法受到了越来越大的挑战，间接工具在打击兴奋剂方面必然会发挥更大的作用。其中一种工具是运动员生物护照（ABP）——对测量的血液学和生物化学生物标志物进行纵向分析，并结合计算得出的分数，同时参考对兴奋剂检测至关重要的流行病学数据。ABP 有血液学和类固醇学两个模块，其参数采用贝叶斯自适应模型进行分析，该模型针对每个个体的参考值和截止值进行了个性化设置，以提高其灵敏度。它考虑了已知和潜在影响生物标志物的混杂因素，如种族和海拔暴露。ABP 已经改变了对抗兴奋剂的斗争，但随着新模块（例如内分泌模块）、参数（例如与血浆体积无关的参数）和补充间接方法（例如转录组学）的出现，其重要性将进一步增加。
