Department of Ophthalmology and Optometry, Eye and ENT Hospital of Fudan University, Shanghai, China.
NHC Key Laboratory of Myopia (Fudan University), Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China.
BMC Ophthalmol. 2024 Mar 28;24(1):143. doi: 10.1186/s12886-024-03409-6.
To investigate the correlation of angles α and κ with the refractive and biological parameters in children.
This case-series study included 438 eyes of 219 children (males/females = 105/114, age: 3-15 years). Ocular biometric parameters, including axial length, corneal radius of curvature (CR), white-to-white distance (WTW), angle κ and angle α, were measured using IOL Master 700; auto-refraction were assessed under cycloplegia. The eyes were assigned to different groups based on CR, WTW, and gender to compare the angles α and κ, and analyze the correlations between the differences of biological parameters on angles α and κ.
The means of axial length, CR, WTW, angle α, and angle κ were 23.24 ± 1.14 mm, 7.79 ± 0.27 mm, 11.68 ± 0.41 mm, 0.45 ± 0.25 mm, and 0.27 ± 0.22 mm, respectively. Angle α was correlated with CR and WTW (fixed effect coefficient [FEC] = 0.237, p = 0.015; FEC = -0.109, p = 0.003; respectively), and angle κ also correlated with CR and WTW (FEC = 0.271, p = 0.003; FEC = -0.147, p < 0.001, respectively). Comparing subgroups, the large CR and small WTW group had larger angles α (0.49 ± 0.27 vs. 0.41 ± 0.21, p < 0.001; 0.46 ± 0.27 vs. 0.44 ± 0.21, p < 0.05, respectively) and κ (0.29 ± 0.25 vs. 0.24 ± 0.15, p < 0.01; 0.29 ± 0.25 vs. 0.26 ± 0.19, p < 0.05, respectively). The differences in interocular angles α and κ showed correlation with interocular WTW (r = - 0.255, p < 0.001; r = - 0.385, p < 0.001). Eyes with smaller WTW tended to have larger angle κ (0.28 ± 0.27 vs. 0.25 ± 0.15, p < 0.05).
The size of angle α/κ may be correlated to CR and WTW, and a larger WTW eye may suggest a smaller angle κ compared with the fellow eye.
探讨儿童的角 α 和 κ 与屈光和生物学参数的相关性。
本病例系列研究纳入了 219 名儿童的 438 只眼（男/女=105/114，年龄：3-15 岁）。使用 IOL Master 700 测量眼生物测量参数，包括眼轴长度、角膜曲率半径（CR）、白到白距离（WTW）、角 κ 和角 α；在睫状肌麻痹下进行自动折射。根据 CR、WTW 和性别将眼分为不同组，比较角 α 和 κ，分析角 α 和 κ 上的生物学参数差异之间的相关性。
眼轴长度、CR、WTW、角 α 和角 κ 的平均值分别为 23.24±1.14mm、7.79±0.27mm、11.68±0.41mm、0.45±0.25mm 和 0.27±0.22mm。角 α 与 CR 和 WTW 相关（固定效应系数[FEC]分别为 0.237，p=0.015；FEC=-0.109，p=0.003），角 κ 也与 CR 和 WTW 相关（FEC 分别为 0.271，p=0.003；FEC=-0.147，p<0.001）。在亚组比较中，大 CR 和小 WTW 组的角 α 较大（0.49±0.27 与 0.41±0.21，p<0.001；0.46±0.27 与 0.44±0.21，p<0.05，分别）和 κ（0.29±0.25 与 0.24±0.15，p<0.01；0.29±0.25 与 0.26±0.19，p<0.05，分别）。双眼间角 α 和 κ 的差异与双眼间 WTW 呈相关性（r=-0.255，p<0.001；r=-0.385，p<0.001）。WTW 较小的眼倾向于有较小的角 κ（0.28±0.27 与 0.25±0.15，p<0.05）。
角 α/κ 的大小可能与 CR 和 WTW 相关，与对侧眼相比，较大的 WTW 眼可能提示较小的角 κ。
