白细胞介素 6 和肿瘤坏死因子 α 在无活性多发性硬化症和并存桥本甲状腺炎患者唾液和血液中的浓度。
THE CONCENTRATION OF INTERLEUKIN 6 AND TUMOR NECROSIS FACTOR ALPHA IN SALIVA AND BLOOD OF PATIENTS WITH INACTIVE MULTIPLE SCLEROSIS AND COEXISTING HASHIMOTO'S THYROIDITIS.
机构信息
Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
Department of Gastroenterology and Hepatology, Zagreb University Hospital Center, Zagreb, Croatia.
出版信息
Acta Clin Croat. 2023 Aug;62(2):339-344. doi: 10.20471/acc.2023.62.02.12.
The concentration of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) in the blood is higher in patients with active multiple sclerosis (MS) compared to those with inactive disease. The concentration of IL-6 and TNF-α in the blood is higher in patients with Hashimoto's thyroiditis (HT) compared to those with a healthy thyroid. The aim of the study was to assess whether serum IL-6 and TNF-α levels correlated with saliva in patients with inactive MS and whether there was a difference in these groups of patients depending of thyroid status. We also examined the correlation of thyroid stimulating hormone (TSH) levels with thyroid status. The study included 54 patients in the inactive phase of MS. The level of cytokines in the blood was determined by chemiluminescence, and in saliva by ELISA. Blood and saliva IL-6 levels showed positive correlation, while blood and saliva TNF-α levels were not correlated. There was a significantly higher TSH level in patients with inactive MS with positive thyroid antibodies, without therapy, compared with those with negative antibodies.
与处于疾病静止期的多发性硬化症（MS）患者相比，活动期 MS 患者血液中白细胞介素 6（IL-6）和肿瘤坏死因子 α（TNF-α）的浓度更高。与甲状腺功能正常的患者相比，桥本甲状腺炎（HT）患者血液中 IL-6 和 TNF-α 的浓度更高。本研究旨在评估处于疾病静止期 MS 患者的血清 IL-6 和 TNF-α 水平是否与唾液相关，以及这些患者群体是否因甲状腺状态而存在差异。我们还检查了促甲状腺激素（TSH）水平与甲状腺状态的相关性。该研究纳入了 54 例处于疾病静止期的 MS 患者。通过化学发光法测定血液中细胞因子的水平，通过 ELISA 法测定唾液中的细胞因子水平。血液和唾液中的 IL-6 水平呈正相关，而血液和唾液中的 TNF-α 水平则没有相关性。与阴性抗体的患者相比，无治疗的抗甲状腺抗体阳性的静止期 MS 患者 TSH 水平显著更高。
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