Masso-Silva Jorge A, Byun Min Kwang, Alexander Laura E Crotty
Department of Medicine, Division of Pulmonary, Critical Care & Sleep Medicine, University of California San Diego, San Diego, CA, United States.
Division of Pulmonology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Curr Opin Physiol. 2021 Aug;22. doi: 10.1016/j.cophys.2021.06.001. Epub 2021 Jun 11.
The impact of e-cigarette use on the inflammatory state and function of the lungs is not well understood. Here we review the latest studies on the impact of short and long term e-cigarette aerosol inhalation on molecular pathways, cellular recruitment, gas exchange and airway physiology. Inflammatory cytokines IL-6 and IL-8 were increased by e-cigarette exposures, and a variety of immune cells were recruited to the parenchyma and airways across models. While there are few consistent signals across , and human studies, due to the multitude of different e-devices and the combination of chemicals within different aerosols generated, it is clear that use of e-cigarettes does alter the inflammatory state and function of the lungs with both acute and chronic use. This is evidenced by the multitude of inflammatory lung diseases already tied to e-cigarette use, but the causal chemicals are primarily remain at large.
电子烟使用对肺部炎症状态和功能的影响尚未得到充分了解。在此，我们综述了关于短期和长期吸入电子烟气溶胶对分子途径、细胞募集、气体交换和气道生理学影响的最新研究。电子烟暴露会增加炎性细胞因子白细胞介素-6和白细胞介素-8，并且在各种模型中，多种免疫细胞被募集到肺实质和气道。虽然在动物、体外和人体研究中几乎没有一致的信号，由于存在多种不同的电子设备以及不同气溶胶中化学物质的组合，但很明显，无论是急性还是慢性使用电子烟，都会改变肺部的炎症状态和功能。这已被众多与电子烟使用相关的炎性肺病所证明，但主要的致病化学物质仍大多未知。
