Institute for Innovation in Imaging, Neurovascular Research Unit, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Neurology, Neuroimmunology and Neuro-Infectious Diseases Division, Massachusetts Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Magn Reson Imaging Clin N Am. 2024 May;32(2):375-384. doi: 10.1016/j.mric.2024.01.003. Epub 2024 Feb 6.
Neuroinflammation is a key immune response observed in many neurologic diseases. Although an appropriate immune response can be beneficial, aberrant activation of this response recruits excessive proinflammatory cells to cause damage. Because the central nervous system is separated from the periphery by the blood-brain barrier (BBB) that creates an immune-privileged site, it has its own unique immune cells and immune response. Moreover, neuroinflammation can compromise the BBB causing an influx of peripheral immune cells and factors. Recent advances have brought a deeper understanding of neuroinflammation that can be leveraged to develop more potent therapies and improve patient selection.
神经炎症是许多神经疾病中观察到的关键免疫反应。虽然适当的免疫反应可能是有益的，但这种反应的异常激活会招募过多的促炎细胞造成损伤。由于中枢神经系统通过血脑屏障（BBB）与外周隔开，形成免疫特惠部位，因此它具有自身独特的免疫细胞和免疫反应。此外，神经炎症可损害血脑屏障，导致外周免疫细胞和因子的涌入。最近的进展使人们对神经炎症有了更深入的了解，这可以为开发更有效的治疗方法和改善患者选择提供帮助。
