Vu Long, Koroukian Siran M, Douglas Sara L, Fein Hannah L, Warner David F, Schiltz Nicholas K, Cullen Jennifer, Owusu Cynthia, Sajatovic Martha, Rose Johnie, Martin Richard
Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Palliat Med Rep. 2024 Mar 28;5(1):127-135. doi: 10.1089/pmr.2023.0047. eCollection 2024.
There is a dearth of studies evaluating the utility of reporting prognostication among nursing home (NH) residents with cancer.
To study factors associated with documented less than six-month prognosis, and its relationship with end-of-life (EOL) care quality measures among residents with cancer.
The Surveillance, Epidemiology, and End Results linked with Medicare, and the Minimum Data Set databases was used to identify 20,397 NH residents in the United States with breast, colorectal, lung, pancreatic, or prostate cancer who died between July 2016 and December 2018. Of these, 2205 residents (10.8%) were documented with less than six-month prognosis upon NH admission. Main outcomes were more than one hospitalization, more than one emergency department visit, and any intensive care unit admission within the last 30 days of life as aggressive EOL care markers, as well as admission to hospice, receipt of advance care planning and palliative care, and survival. Specificity and sensitivity of prognosis were assessed using six-month mortality as the outcome. Propensity score matching adjusted for selection biases, and logistic regression examined association.
Specificity and sensitivity of documented less than six-month prognosis for mortality were 94.2% and 13.7%, respectively. Residents with documented less than six-month prognosis had greater odds of being admitted to hospice than those without (adjusted odds ratio: 3.27, 95% confidence interval: 2.86-3.62), and lower odds to receive aggressive EOL care.
In this cohort study, documented less than six-month prognosis was associated with less aggressive EOL care. Despite its high specificity, however, low sensitivity limits its utility to operationalize care on a larger population of residents with terminal illness.
评估疗养院(NH)癌症患者预后报告实用性的研究匮乏。
研究与记录的生存期不足6个月相关的因素,以及其与癌症患者临终(EOL)护理质量指标的关系。
利用与医疗保险相关的监测、流行病学和最终结果数据,以及最小数据集数据库,识别出2016年7月至2018年12月期间在美国死于乳腺癌、结直肠癌、肺癌、胰腺癌或前列腺癌的20397名NH居民。其中,2205名居民(10.8%)在入住NH时被记录为生存期不足6个月。主要结局包括在生命的最后30天内多次住院、多次急诊就诊以及任何重症监护病房入院,作为积极的EOL护理指标,还有入住临终关怀机构、接受预先护理计划和姑息治疗以及生存情况。以6个月死亡率为结局评估预后的特异性和敏感性。倾向评分匹配用于调整选择偏倚,逻辑回归分析关联性。
记录的生存期不足6个月对死亡率的特异性和敏感性分别为94.2%和13.7%。记录的生存期不足6个月的居民入住临终关怀机构的几率高于未记录的居民(调整后的优势比:3.27,95%置信区间:2.86 - 3.62),而接受积极EOL护理的几率较低。
在这项队列研究中,记录的生存期不足6个月与不太积极的EOL护理相关。然而,尽管其特异性较高,但低敏感性限制了其在为更多晚期疾病居民实施护理方面的实用性。