GLP-1 受体激动剂使用对体重较高和较低的女性的负面评价的影响。

The effect of GLP-1 receptor agonist use on negative evaluations of women with higher and lower body weight.

机构信息

The George Washington University, Washington, DC, USA.

Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, MD, USA.

出版信息

Int J Obes (Lond). 2024 Jul;48(7):1019-1026. doi: 10.1038/s41366-024-01516-4. Epub 2024 Apr 1.

DOI:10.1038/s41366-024-01516-4

PMID:38561488

Abstract

BACKGROUND

GLP-1 receptor agonists (GLP-1 RAs) have dramatically altered obesity treatment. Media reports suggest that GLP-1 RAs users often report feeling judged for taking a "shortcut" to lose weight, which may be related to negative stereotypes toward people with larger bodies. Media reports also describe negative attitudes about lean people who take GLP-1 RAs to enhance their appearance. The present research used a 2 × 2 experimental design to test the effects of GLP-1 RA use and body size on attitudes and egocentric impressions.

SUBJECTS/METHODS: A sample of 357 U.S. adults (M = 37.8, SD = 13) were randomly assigned to read about a woman, who either was lean or had obesity, and who lost 15% of her body weight either with diet/exercise or a GLP-1 RA. Participants answered questions measuring endorsement of negative weight-related stereotypes and egocentric attitudes toward the woman, as well as beliefs that she took a shortcut to lose weight and beliefs that biogenetic factors caused her baseline weight.

RESULTS

Negative evaluations and egocentric impressions were stronger toward a woman who lost weight with a GLP-1 RA compared to diet/exercise. Losing weight with a GLP-1 RA led to stronger negative evaluations through higher weight loss shortcut beliefs irrespective of body size. Losing weight with a GLP-1 RA also led to higher egocentric impressions through higher shortcut beliefs, and this effect was stronger for a lean woman. Finally, losing weight with a GLP-1 RA led to more negative evaluations through stronger endorsement of biogenetic causal beliefs for a lean woman only.

CONCLUSIONS

This timely study provides evidence that people with larger and smaller bodies alike are at-risk for being judged for using GLP-1 RAs due to beliefs that these medications are a shortcut. Findings also demonstrate novel reactions related to egotism when weight loss is achieved with pharmacological interventions. PRE-REGISTRATION AND DATA: osf.io/xme4w.

摘要

背景

GLP-1 受体激动剂（GLP-1 RAs）极大地改变了肥胖症的治疗方法。媒体报道称，GLP-1 RA 用户经常因服用“捷径”减肥药而感到被评判，这可能与人们对大体重者的负面刻板印象有关。媒体报道还描述了瘦人使用 GLP-1 RAs 来改善外貌的负面态度。本研究采用 2×2 实验设计，测试 GLP-1 RA 使用和体型对态度和自我中心印象的影响。

受试者/方法：一项针对 357 名美国成年人（M=37.8，SD=13）的样本被随机分配阅读一位女性的信息，该女性要么身材苗条，要么肥胖，并通过饮食/运动或 GLP-1 RA 减掉了 15%的体重。参与者回答了一些问题，这些问题衡量了对负面与体重相关的刻板印象和对该女性的自我中心态度的认同程度，以及对她采取捷径减肥的信念和导致她基础体重的生物遗传因素的信念。

结果

与通过饮食/运动减肥的女性相比，通过 GLP-1 RA 减肥的女性会受到更负面的评价和自我中心的印象。通过 GLP-1 RA 减肥会导致更强的负面评价，这是由于更高的减肥捷径信念，而与体型大小无关。通过 GLP-1 RA 减肥也会通过更高的捷径信念导致更高的自我中心印象，而对于苗条的女性，这种影响更强。最后，只有对于苗条的女性，通过 GLP-1 RA 减肥会通过更强的生物遗传因果信念认同导致更负面的评价。