Cerezo Gustavo H, Fernández Ruth A, Enders Julio E, Vicario Augusto
Heart and Brain Unit. ICBA-Cardiovascular Institute, Buenos Aires, Argentina.
Health Public School. Córdoba National University, Córdoba, Argentina.
Hypertens Res. 2024 Jun;47(6):1728-1734. doi: 10.1038/s41440-024-01650-6. Epub 2024 Apr 2.
In spite of the fact that hypertension stand out as the main vascular risk factor for developing dementia, it is essential to acknowledge the presence of other risk factors, both vascular and non-vascular that contribute to increase this risk. This study stratified the dementia risk using CAIDE (Cardiovascular Risk Factors, Aging, and Incidence of Dementia) dementia risk score in a sample of 1279 hypertensive patients from the Heart-Brain Study in Argentina and to observed the association between the risk factors include in the CAIDE score and the current cognitive status. The average age of the sample was 60.2 ± 13.5 years (71% female) and the average years of education was 9.9 ± 5.1 years. To assess the current cognitive status, we used the Mini-mental test (MMSE), the clock drawing test (CDT) and Mini-Boston test. According to CAIDE score ( ≥9 points) the risk of dementia was 40.4% in the total sample and 28.1% in the middle-life hypertensive patients (between 47 to 53 years). An inverse association was observed between CAIDE score and the results of current cognitive tests (MMSE = R2 0.9128, p < 0.0001; CDT = R2 0.9215, p < 0.0001 y Mini-Boston= R2 0.829, p < 0.0001). The CAIDE score can predict the risk of dementia in hypertensive patients and its result was associated with the current cognitive status (result of cognitive tests).
尽管高血压是导致痴呆症的主要血管危险因素，但必须认识到还有其他血管性和非血管性危险因素会增加这种风险。本研究在阿根廷心脏-大脑研究中的1279名高血压患者样本中，使用CAIDE（心血管危险因素、衰老与痴呆症发病率）痴呆风险评分对痴呆风险进行分层，并观察CAIDE评分中包含的危险因素与当前认知状态之间的关联。样本的平均年龄为60.2±13.5岁（71%为女性），平均受教育年限为9.9±5.1年。为评估当前认知状态，我们使用了简易精神状态检查（MMSE）、画钟试验（CDT）和迷你波士顿试验。根据CAIDE评分（≥9分），总样本中痴呆风险为40.4%，中年高血压患者（47至53岁）中为28.1%。观察到CAIDE评分与当前认知测试结果之间存在负相关（MMSE = R2 0.9128，p < 0.0001；CDT = R2 0.9215，p < 0.0001；迷你波士顿试验 = R2 0.829，p < 0.0001）。CAIDE评分可以预测高血压患者的痴呆风险，其结果与当前认知状态（认知测试结果）相关。
