Department of Anesthesiology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
School of Medicine, Xiamen University, Xiamen, China.
Int J Stroke. 2024 Jul;19(6):686-694. doi: 10.1177/17474930241246955. Epub 2024 Apr 19.
Stroke is the second leading cause of death and the leading cause of disability worldwide. However, how the prevalence of stroke varies across the world is uncertain.
The aim of this study was to analyze temporal trends of prevalence for stroke, including ischemic stroke (IS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) at the global, regional, and national levels.
The age-standardized prevalence rates (ASPR) of stroke, IS, ICH, and SAH, along with their corresponding 95% uncertainty intervals (UI), were derived from data in the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. This provides estimates for the burden of 369 diseases and injuries globally in 2019, as well as their temporal trends over the past 30 years. Joinpoint regression analysis was used to analyze the 1990-2019 temporal trends by calculating the annual percentage change (APC) and average annual percentage change (AAPC), as well as their 95% confidence interval (CI).
In 2019, the global ASPR of stroke was 1240.263 per 100,000 population (95% UI: 1139.711 to 1352.987), with ASPRs generally lower in Europe compared to other regions. Over the period from 1990 to 2019, a significant global decrease in ASPR was observed for stroke (AAPC -0.200, 95% CI: -0.215 to -0.183), IS (AAPC -0.059%, 95% CI: -0.077 to -0.043), SAH (AAPC -0.476, 95% CI: -0.483 to -0.469), and ICH (AAPC -0.626, 95% CI: -0.642 to -0.611). The trends of ASPR of stroke, IS, SAH, and ICH varied significantly across 204 countries and territories.
Our findings highlight significant global disparities in stroke prevalence, emphasizing the need for ongoing monitoring and intensified efforts in developing regions to reduce the global burden of stroke.
中风是全球范围内的第二大致死原因和首要致残原因。然而，全球范围内中风的流行程度如何尚不确定。
本研究旨在分析全球、地区和国家层面中风（包括缺血性中风[IS]、脑出血[ICH]和蛛网膜下腔出血[SAH]）流行率的时间趋势。
中风、IS、ICH 和 SAH 的年龄标准化患病率（ASPR）及其相应的 95%置信区间（UI）源自 2019 年全球疾病、伤害和危险因素研究（GBD）的数据。该研究提供了 2019 年全球 369 种疾病和伤害的负担估计值，以及过去 30 年的时间趋势。采用 Joinpoint 回归分析来分析 1990-2019 年的时间趋势，通过计算年变化百分比（APC）和平均年变化百分比（AAPC）及其 95%置信区间（CI）来实现。
2019 年，全球中风的 ASPR 为 1240.263/100,000 人（95%UI：1139.711 至 1352.987），欧洲的 ASPR 普遍低于其他地区。在 1990 年至 2019 年期间，中风（AAPC-0.200，95%CI：-0.215 至-0.183）、IS（AAPC-0.059%，95%CI：-0.077 至-0.043）、SAH（AAPC-0.476，95%CI：-0.483 至-0.469）和 ICH（AAPC-0.626，95%CI：-0.642 至-0.611）的全球 ASPR 均显著下降。204 个国家和地区中风、IS、SAH 和 ICH 的 ASPR 趋势存在显著差异。
本研究结果突显了中风流行率在全球范围内存在显著差异，强调了在发展中地区持续监测和加强努力以降低全球中风负担的必要性。
