Trang L E, Granström E, Lövgren O
Scand J Rheumatol. 1977;6(3):151-4. doi: 10.3109/03009747709095440.
Prostaglandin F2 alpha (PGF2 alpha), prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) levels were determined by radioimmunoassay (RIA) in knee joint fluid in two groups of patients with classical or definite rheumatoid arthritis (RA). One group had no treatment for one week prior to the study. The second group consisted of patients who developed acute exudative arthritis despite the use of various non-steroidal anti-inflammatory drugs (NSAID). The main metabolites of PGF2 alpha in plasma and urine were measured in the untreated group. The conclusion to be drawn from this study are: 1) Treatment with NSAID effectively lowers PGF2 alpha and PGE2 and TXB2 levels in joint fluid. 2) Signs and symptoms of arthritis may persist in spite of lowered levels of PGF2 alpha and PGE2 in the joint fluid. 3) The main metabolites of PGF2 alpha in plasma and urine are above the low-normal limit in untreated patients. 4) The ratio TXB2/PG was low in untreated patients, suggesting that the thromboxane pathway is quantitatively minor in rheumatoid joint inflammation.
采用放射免疫分析法（RIA）测定了两组典型或确诊类风湿性关节炎（RA）患者膝关节液中前列腺素F2α（PGF2α）、前列腺素E2（PGE2）和血栓素B2（TXB2）的水平。一组在研究前一周未接受治疗。第二组由尽管使用了各种非甾体抗炎药（NSAID）仍发生急性渗出性关节炎的患者组成。在未治疗组中测量了血浆和尿液中PGF2α的主要代谢产物。从本研究中得出的结论如下：1）NSAID治疗可有效降低关节液中PGF2α、PGE2和TXB2的水平。2）尽管关节液中PGF2α和PGE2水平降低，但关节炎的体征和症状可能持续存在。3）未治疗患者血浆和尿液中PGF2α的主要代谢产物高于低正常范围。4）未治疗患者的TXB2/PG比值较低，表明在类风湿性关节炎症中血栓素途径在数量上占比小。
