Popescu N C, Amsbaugh S C, DiPaolo J A, Tronick S R, Aaronson S A, Swan D C
Somat Cell Mol Genet. 1985 Mar;11(2):149-55. doi: 10.1007/BF01534703.
Three human ras family protooncogenes, c-Ki-ras-1, and c-Ki-ras-2, and N-ras, have been mapped to chromosome bands 6p11-12, 12p11.1-12.1, and 1p11-13, respectively by in situ molecular hybridization. Certain human cancers display consistent and specific alterations involving chromosomes 1, 6, and 12. The precise chromosomal localization of ras genes will permit evaluation of the possible effect of these chromosome changes on the structure and activities of ras protooncogenes in human neoplasia.
通过原位分子杂交技术，已将三种人类ras家族原癌基因，即c-Ki-ras-1、c-Ki-ras-2和N-ras，分别定位到6号染色体带6p11-12、12号染色体带12p11.1-12.1和1号染色体带1p11-13。某些人类癌症表现出涉及1号、6号和12号染色体的一致且特定的改变。ras基因精确的染色体定位将有助于评估这些染色体变化对人类肿瘤形成中ras原癌基因的结构和活性可能产生的影响。
