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卡塔尔 COVID-19 患者入住重症监护病房的早期预测指标。

Early predictors of intensive care unit admission among COVID-19 patients in Qatar.

机构信息

Department of Pharmacy, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.

Department of Pharmacy, Hamad Bin Khalifa Medical City, Hamad Medical Corporation, Doha, Qatar.

出版信息

Front Public Health. 2024 Mar 20;12:1278046. doi: 10.3389/fpubh.2024.1278046. eCollection 2024.

DOI:10.3389/fpubh.2024.1278046
PMID:38572008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10987715/
Abstract

BACKGROUND

COVID-19 is associated with significant morbidity and mortality. This study aimed to explore the early predictors of intensive care unit (ICU) admission among patients with COVID-19.

METHODS

This was a case-control study of adult patients with confirmed COVID-19. Cases were defined as patients admitted to ICU during the period February 29-May 29, 2020. For each case enrolled, one control was matched by age and gender.

RESULTS

A total of 1,560 patients with confirmed COVID-19 were included. Each group included 780 patients with a predominant male gender (89.7%) and a median age of 49 years (interquartile range = 18). Predictors independently associated with ICU admission were cardiovascular disease (adjusted odds ratio (aOR) = 1.64, 95% confidence interval (CI): 1.16-2.32, = 0.005), diabetes (aOR = 1.52, 95% CI: 1.08-2.13, = 0.016), obesity (aOR = 1.46, 95% CI: 1.03-2.08, = 0.034), lymphopenia (aOR = 2.69, 95% CI: 1.80-4.02, < 0.001), high AST (aOR = 2.59, 95% CI: 1.53-4.36, < 0.001), high ferritin (aOR = 1.96, 95% CI: 1.40-2.74, < 0.001), high CRP (aOR = 4.09, 95% CI: 2.81-5.96, < 0.001), and dyspnea (aOR = 2.50, 95% CI: 1.77-3.54, < 0.001).

CONCLUSION

Having cardiovascular disease, diabetes, obesity, lymphopenia, dyspnea, and increased AST, ferritin, and CRP were independent predictors for ICU admission in patients with COVID-19.

摘要

背景

COVID-19 与显著的发病率和死亡率相关。本研究旨在探索 COVID-19 患者入住重症监护病房（ICU）的早期预测因素。

方法

这是一项对 2020 年 2 月 29 日至 5 月 29 日期间确诊 COVID-19 的成年患者进行的病例对照研究。病例定义为入住 ICU 的患者。为每个纳入的病例匹配一名年龄和性别相匹配的对照。

结果

共纳入 1560 例确诊 COVID-19 患者。每组包括 780 名主要为男性（89.7%）和中位年龄为 49 岁（四分位间距=18）的患者。与 ICU 入院相关的独立预测因素包括心血管疾病（调整后的优势比（aOR）=1.64，95%置信区间（CI）：1.16-2.32，=0.005）、糖尿病（aOR=1.52，95%CI：1.08-2.13，=0.016）、肥胖症（aOR=1.46，95%CI：1.03-2.08，=0.034）、淋巴细胞减少症（aOR=2.69，95%CI：1.80-4.02，<0.001）、高 AST（aOR=2.59，95%CI：1.53-4.36，<0.001）、高铁蛋白血症（aOR=1.96，95%CI：1.40-2.74，<0.001）、高 CRP（aOR=4.09，95%CI：2.81-5.96，<0.001）和呼吸困难（aOR=2.50，95%CI：1.77-3.54，<0.001）。

结论

患有心血管疾病、糖尿病、肥胖症、淋巴细胞减少症、呼吸困难以及 AST、铁蛋白和 CRP 升高是 COVID-19 患者入住 ICU 的独立预测因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d53a/10987715/2d40d1bfe83f/fpubh-12-1278046-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d53a/10987715/38cfedda5961/fpubh-12-1278046-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d53a/10987715/2d40d1bfe83f/fpubh-12-1278046-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d53a/10987715/38cfedda5961/fpubh-12-1278046-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d53a/10987715/2d40d1bfe83f/fpubh-12-1278046-g002.jpg

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