人类α-干扰素样序列家族

Family of human alpha-interferon-like sequences.

作者信息

Feinstein S I, Mory Y, Chernajovsky Y, Maroteaux L, Nir U, Lavie V, Revel M

出版信息

Mol Cell Biol. 1985 Mar;5(3):510-7. doi: 10.1128/mcb.5.3.510-517.1985.

DOI:10.1128/mcb.5.3.510-517.1985

PMID:3857460

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC366743/

Abstract

An interferon-alpha-like sequence was isolated from a human genomic library by hybridization with a 15-base oligonucleotide. The sequence also showed homology to alpha-interferon and was most closely related to the leukocyte interferon-M gene fragment. The original isolate cross-hybridized to a family of sequences, 10 of which were isolated as clones. Some of these sequences were located within a few kilobases of alpha-interferon genes, consistent with our assignment of several members of the family to human chromosome 9 which also has the beta 1- and alpha-interferon genes.

摘要

通过与一个15碱基的寡核苷酸杂交，从人类基因组文库中分离出一个类α干扰素序列。该序列也显示出与α干扰素的同源性，并且与白细胞干扰素-M基因片段关系最为密切。最初分离的序列与一系列序列发生交叉杂交，其中10个作为克隆被分离出来。这些序列中的一些位于α干扰素基因的几千碱基范围内，这与我们将该家族的几个成员定位到人类9号染色体上的结果一致，9号染色体上也有β1干扰素基因和α干扰素基因。