Blood Bank and Transfusion Medicine Unit, Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
Human Genetic Unit, Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
Sci Rep. 2024 Apr 4;14(1):7920. doi: 10.1038/s41598-024-57584-z.
Blood safety is a critical aspect of healthcare systems worldwide involving rigorous screening, testing, and processing protocols to minimize the risk of transfusion-transmitted infections (TTIs). The present study offers a comprehensive assessment of the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and syphilis among blood donors in southern Thailand. It explores the consequences of the COVID-19 pandemic on the blood transfusion service, donor characteristics, and the prevalence of TTIs. A retrospective analysis of 65,511 blood donors between 2018 and 2022 was conducted at Songklanagarind Hospital, Thailand. The socio-demographic characteristics of the donors were examined using the Chi-square test to assess the relationship between TTIs serological positivity and donor characteristics. The donors were divided into pre-COVID-19 (2018-2019) and during COVID-19 (2020-2022) groups to evaluate the impacts of COVID-19. The study found that HBV had the highest overall prevalence at 243 per hundred thousand (pht), followed by syphilis (118 pht), HCV (32 pht), and HIV (31 pht) over a five-year period of study. After COVID-19, the prevalence of HBV decreased by 21.8%; HCV decreased by 2.1%; HIV increased by 36.4%; and syphilis increased by 9.2%. The socio-demographic characteristics and TTIs prevalence were significantly altered over time. This study provides insights into blood donor characteristics and TTIs prevalence in southern Thailand, highlighting the understanding of the impact of COVID-19 on the spread of TTIs.
血液安全是全球医疗体系的关键环节，涉及严格的筛查、检测和处理方案，以最大程度降低输血传播感染（TTIs）的风险。本研究全面评估了泰国南部献血者中乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）、人类免疫缺陷病毒（HIV）和梅毒的流行情况。它探讨了 COVID-19 大流行对输血服务、献血者特征和 TTIs 流行率的影响。对泰国宋卡王子大学医院 2018 年至 2022 年间的 65511 名献血者进行了回顾性分析。使用卡方检验评估 TTIs 血清学阳性与献血者特征之间的关系，分析献血者的社会人口统计学特征。将献血者分为 COVID-19 前（2018-2019 年）和 COVID-19 期间（2020-2022 年）两组，以评估 COVID-19 的影响。研究发现，HBV 的总体流行率最高，为每十万分之 243（pht），其次是梅毒（118 pht）、HCV（32 pht）和 HIV（31 pht），研究期间为五年。COVID-19 后，HBV 的流行率下降了 21.8%；HCV 下降了 2.1%；HIV 增加了 36.4%；梅毒增加了 9.2%。社会人口统计学特征和 TTIs 流行率随时间显著改变。本研究提供了泰国南部献血者特征和 TTIs 流行率的见解，强调了对 COVID-19 对 TTIs 传播影响的理解。
