牛奶对大肠杆菌的抑菌作用。IV. 人乳的抑菌抗体。
Bacteriostasis of Escherichia coli by milk. IV. The bacteriostatic antibody of human milk.
作者信息
Dolby J M, Honour P
出版信息
J Hyg (Lond). 1979 Oct;83(2):255-65. doi: 10.1017/s0022172400026048.
Abstract
Bacteriostatic activity for milk-sensitive and milk-resistant strains of Escherichia coli is reduced when IgA is removed from milk by precipitation. Lysozyme is not involved in bacteriostasis and can be removed without loss of activity; heavy bentonite absorption however removes some lactoferrin causing partial loss of activity. The heat-labile antigen eliciting bacteriostatic antibody for E. coli is present in milk-sensitive and milk-resistant strains and in some other Enterobacteriaceae, e.g. salmonella; it cross reacts with the antigen in others, e.g. proteus and enterobacter. The antibody is therefore likely to be present in all human milk as a result of the normal commensal gut flora and with widespread activity.
摘要
当通过沉淀从牛奶中去除IgA时，对牛奶敏感和牛奶抗性的大肠杆菌菌株的抑菌活性会降低。溶菌酶不参与抑菌作用，去除它不会导致活性丧失；然而，用重质膨润土吸附会去除一些乳铁蛋白，导致部分活性丧失。引发针对大肠杆菌的抑菌抗体的热不稳定抗原存在于牛奶敏感和牛奶抗性菌株以及其他一些肠杆菌科细菌中，例如沙门氏菌；它与其他细菌中的抗原发生交叉反应，例如变形杆菌和肠杆菌。因此，由于正常的肠道共生菌群，这种抗体可能存在于所有人乳中，并且具有广泛的活性。
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