Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Frankfurt am Main, Germany.
Department 15, Biosciences, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.
Blood. 2024 Jul 4;144(1):21-34. doi: 10.1182/blood.2023023788.
Hematopoietic stem cells (HSCs) are instrumental for organismal survival because they are responsible for lifelong production of mature blood lineages in homeostasis and response to external stress. To fulfill their function, HSCs rely on reciprocal interactions with specialized tissue microenvironments, termed HSC niches. From embryonic development to advanced aging, HSCs transition through several hematopoietic organs in which they are supported by distinct extrinsic cues. Here, we describe recent discoveries on how HSC niches collectively adapt to ensure robust hematopoietic function during biological aging and after exposure to acute stress. We also discuss the latest strategies leveraging niche-derived signals to revert aging-associated phenotypes and enhance hematopoietic recovery after myeloablation.
造血干细胞（HSCs）对于生物体的生存至关重要，因为它们负责在体内平衡和对外界应激做出反应的情况下终身产生成熟的血液谱系。为了发挥其功能，HSCs 依赖于与专门的组织微环境（称为 HSC 龛）的相互作用。从胚胎发育到高级衰老，HSCs 经历几个造血器官，在这些器官中，它们受到不同的外在线索的支持。在这里，我们描述了最近的发现，即 HSC 龛如何协同适应，以确保在生物衰老和急性应激后具有强大的造血功能。我们还讨论了利用龛衍生信号来逆转与衰老相关的表型并增强骨髓清除后造血恢复的最新策略。
