• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

骨髓相关间充质干细胞变化的研究。

Study on the changes of human bone marrow‑related mesenchymal stem cells.

机构信息

Department of Histology and Embryology, Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing 400016, P.R. China.

Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.

出版信息

Int J Mol Med. 2025 Feb;55(2). doi: 10.3892/ijmm.2024.5464. Epub 2024 Nov 29.

DOI:10.3892/ijmm.2024.5464
PMID:39611467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11637496/
Abstract

Bone marrow mesenchymal stem cells (MSCs) serve a pivotal role in the hematopoietic niche. The present study collected bone marrow samples from individuals across various age groups to investigate the biological characteristics of MSCs. By modifying the bone marrow microenvironment through co‑culture techniques, changes in the stemness of MSCs were examined. An hematopoietic co‑culture system was established to simulate the impact of MSCs on hematopoietic stem cells. The results demonstrated that the mode of cell‑to‑cell contact among stem cells is more influential in shaping bone marrow function compared with the effects of aging on these stem cells. Transcriptomic analysis revealed that MSCs serve as essential mediators, with their growth variations being both a consequence and a cause of changes in the bone marrow microenvironment. Furthermore, the decline in hematopoietic function observed in the elderly is a manifestation of this phenomenon. Data from the present study suggest that targeting MSCs is essential for enhancing bone marrow function and improving the outcomes of bone marrow transplantation.

摘要

骨髓间充质干细胞（MSCs）在造血龛中起着关键作用。本研究收集了来自不同年龄组个体的骨髓样本，以研究 MSCs 的生物学特性。通过共培养技术改变骨髓微环境，观察 MSCs 干性的变化。建立了一个造血共培养系统来模拟 MSCs 对造血干细胞的影响。结果表明，与衰老对这些干细胞的影响相比，干细胞之间的细胞接触方式对塑造骨髓功能的影响更大。转录组分析表明，MSCs 是重要的介质，其生长变化既是骨髓微环境变化的结果，也是其原因。此外，老年人观察到的造血功能下降就是这种现象的表现。本研究的数据表明，针对 MSCs 对于增强骨髓功能和改善骨髓移植的结果至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/8428f6eaa062/ijmm-55-02-05464-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/0a1c61ebfca8/ijmm-55-02-05464-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/dea0f3c77a84/ijmm-55-02-05464-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/c1e17ee8efb8/ijmm-55-02-05464-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/996b72036542/ijmm-55-02-05464-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/3fd9b01d7ee1/ijmm-55-02-05464-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/9d09296a3387/ijmm-55-02-05464-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/1e532a2cdb05/ijmm-55-02-05464-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/23e8f5496511/ijmm-55-02-05464-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/8428f6eaa062/ijmm-55-02-05464-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/0a1c61ebfca8/ijmm-55-02-05464-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/dea0f3c77a84/ijmm-55-02-05464-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/c1e17ee8efb8/ijmm-55-02-05464-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/996b72036542/ijmm-55-02-05464-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/3fd9b01d7ee1/ijmm-55-02-05464-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/9d09296a3387/ijmm-55-02-05464-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/1e532a2cdb05/ijmm-55-02-05464-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/23e8f5496511/ijmm-55-02-05464-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33e9/11637496/8428f6eaa062/ijmm-55-02-05464-g08.jpg

相似文献

1
Study on the changes of human bone marrow‑related mesenchymal stem cells.骨髓相关间充质干细胞变化的研究。
Int J Mol Med. 2025 Feb;55(2). doi: 10.3892/ijmm.2024.5464. Epub 2024 Nov 29.
2
Human olfactory mucosa multipotent mesenchymal stromal cells promote survival, proliferation, and differentiation of human hematopoietic cells.人嗅黏膜多能间充质基质细胞促进人造血细胞的存活、增殖和分化。
Stem Cells Dev. 2012 Nov 20;21(17):3187-96. doi: 10.1089/scd.2012.0084. Epub 2012 May 18.
3
Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model.成骨细胞和骨髓间充质基质细胞在 3D 体外模型中控制造血干细胞的迁移和增殖。
PLoS One. 2010 Feb 8;5(2):e9093. doi: 10.1371/journal.pone.0009093.
4
Influence of mesenchymal stem cells derived from bone marrow of children with oncohematological diseases on proliferation and self-renewal of hematopoietic progenitor cells in vitro.肿瘤血液学疾病患儿骨髓间充质干细胞对造血祖细胞体外增殖及自我更新的影响
Exp Oncol. 2008 Jun;30(2):121-8.
5
Establishment of bone marrow and hematopoietic niches in vivo by reversion of chondrocyte differentiation of human bone marrow stromal cells.通过逆转人骨髓基质细胞的软骨细胞分化在体内建立骨髓和造血微环境。
Stem Cell Res. 2014 May;12(3):659-72. doi: 10.1016/j.scr.2014.01.006. Epub 2014 Feb 8.
6
Functional mesenchymal stem cells remain present in bone marrow microenvironment of patients with leukemia post-allogeneic hematopoietic stem cell transplant.在异基因造血干细胞移植后的白血病患者的骨髓微环境中，功能性间充质干细胞仍然存在。
Leuk Lymphoma. 2014 Jul;55(7):1635-44. doi: 10.3109/10428194.2013.858815. Epub 2014 Feb 14.
7
Mesenchymal stromal cells derived from the bone marrow of acute lymphoblastic leukemia patients show altered BMP4 production: correlations with the course of disease.骨髓间充质基质细胞来源于急性淋巴细胞白血病患者，其 BMP4 的产生发生改变：与疾病进程的相关性。
PLoS One. 2014 Jan 6;9(1):e84496. doi: 10.1371/journal.pone.0084496. eCollection 2014.
8
Human umbilical cord mesenchymal stem cells improve bone marrow hematopoiesis through regulation of bone marrow adipose tissue.人脐带间充质干细胞通过调节骨髓脂肪组织改善骨髓造血功能。
Mol Cell Biochem. 2025 May;480(5):3033-3049. doi: 10.1007/s11010-024-05156-0. Epub 2024 Nov 30.
9
Bone marrow mesenchymal stem cells from patients with aplastic anemia maintain functional and immune properties and do not contribute to the pathogenesis of the disease.再生障碍性贫血患者的骨髓间充质干细胞保持功能和免疫特性，且不参与该疾病的发病机制。
Haematologica. 2014 Jul;99(7):1168-75. doi: 10.3324/haematol.2014.103580. Epub 2014 Apr 11.
10
Structural investigation of donor age effect on human bone marrow mesenchymal stem cells: FTIR spectroscopy and imaging.供体年龄对人骨髓间充质干细胞影响的结构研究：傅里叶变换红外光谱法及成像技术
Age (Dordr). 2014;36(4):9691. doi: 10.1007/s11357-014-9691-7. Epub 2014 Aug 1.

本文引用的文献

1
Variation in mesenchymal KITL/SCF and IGF1 expression in middle age underlies steady-state hematopoietic stem cell aging.中年间充质 KITL/SCF 和 IGF1 表达的变化是造血干细胞衰老的基础。
Blood. 2024 Jul 25;144(4):378-391. doi: 10.1182/blood.2024024275.
2
Bone marrow niches for hematopoietic stem cells: life span dynamics and adaptation to acute stress.造血干细胞的骨髓龛：寿命动力学和对急性应激的适应。
Blood. 2024 Jul 4;144(1):21-34. doi: 10.1182/blood.2023023788.
3
Semaphorins and the bone marrow microenvironment: New candidates that influence the hematopoietic system.
信号素及其与骨髓微环境的相互作用：影响造血系统的新候选者。
Cytokine Growth Factor Rev. 2024 Apr;76:22-29. doi: 10.1016/j.cytogfr.2024.02.002. Epub 2024 Feb 27.
4
Mesenchymal stem/stromal cells from human pluripotent stem cell-derived brain organoid enhance the ex vivo expansion and maintenance of hematopoietic stem/progenitor cells.人多能干细胞衍生脑类器官中的间充质干细胞/基质细胞增强了造血干/祖细胞的体外扩增和维持。
Stem Cell Res Ther. 2024 Mar 5;15(1):68. doi: 10.1186/s13287-023-03624-w.
5
Age-related changes in human bone marrow mesenchymal stromal cells: morphology, gene expression profile, immunomodulatory activity and miRNA expression.人类骨髓间充质基质细胞的年龄相关性变化：形态、基因表达谱、免疫调节活性和 miRNA 表达。
Front Immunol. 2023 Dec 7;14:1267550. doi: 10.3389/fimmu.2023.1267550. eCollection 2023.
6
The Bone Marrow Microenvironment in Immune-Mediated Inflammatory Diseases: Implications for Mesenchymal Stromal Cell-Based Therapies.免疫介导的炎症性疾病中的骨髓微环境：对间充质基质细胞为基础的治疗的影响。
Stem Cells Transl Med. 2024 Mar 15;13(3):219-229. doi: 10.1093/stcltm/szad086.
7
Consequences of Aging on Bone.衰老对骨骼的影响。
Aging Dis. 2023 Nov 20;15(6):2417-2452. doi: 10.14336/AD.2023.1115.
8
Evaluation of safety and efficacy of allogeneic adipose tissue-derived mesenchymal stem cells in pediatric bronchiolitis obliterans syndrome (BoS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).评价同种异体脂肪组织来源间充质干细胞在异基因造血干细胞移植（allo-HSCT）后小儿闭塞性细支气管炎综合征（BoS）中的安全性和有效性。
Stem Cell Res Ther. 2023 Sep 19;14(1):256. doi: 10.1186/s13287-023-03498-y.
9
Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials.临床研究中的间充质基质/干细胞（MSC）衍生的外泌体。
Stem Cell Res Ther. 2023 Apr 7;14(1):66. doi: 10.1186/s13287-023-03287-7.
10
Hematopoietic stem cell aging and leukemia transformation.造血干细胞衰老与白血病转化。
Blood. 2023 Aug 10;142(6):533-542. doi: 10.1182/blood.2022017933.