Department of Pharmacy - Pharmaceutical Sciences, University of Bari, Via E. Orabona, 4, 70125, Bari, Italy.
Department of Pharmacy, University of Naples Federico II, D. Montesano St. 49, 80131 Naples, Italy.
J Pharm Sci. 2024 Jul;113(7):1726-1748. doi: 10.1016/j.xphs.2024.04.001. Epub 2024 Apr 4.
The production of paediatric pharmaceutical forms represents a unique challenge within the pharmaceutical industry. The primary goal of these formulations is to ensure therapeutic efficacy, safety, and tolerability in paediatric patients, who have specific physiological needs and characteristics. In recent years, there has been a significant increase in attention towards this area, driven by the need to improve drug administration to children and ensure optimal and specific treatments. Technological innovation has played a crucial role in meeting these requirements, opening new frontiers in the design and production of paediatric pharmaceutical forms. In particular, three emerging technologies have garnered considerable interest and attention within the scientific and industrial community: 3D printing, prilling/vibration, and microfluidics. These technologies offer advanced approaches for the design, production, and customization of paediatric pharmaceutical forms, allowing for more precise dosage modulation, improved solubility, and greater drug acceptability. In this review, we delve into these cutting-edge technologies and their impact on the production of paediatric pharmaceutical forms. We analyse their potential, associated challenges, and recent developments, providing a comprehensive overview of the opportunities that these innovative methodologies offer to the pharmaceutical sector. We examine different pharmaceutical forms generated using these techniques, evaluating their advantages and disadvantages.
儿科药物制剂的生产是制药行业面临的一项独特挑战。这些制剂的主要目标是确保儿科患者的治疗效果、安全性和耐受性，因为儿科患者具有特殊的生理需求和特点。近年来，由于需要改善儿童用药并确保最佳和特定的治疗效果，人们对这一领域的关注度显著提高。技术创新在满足这些需求方面发挥了关键作用，为儿科药物制剂的设计和生产开辟了新的领域。特别是，3D 打印、制粒/振动和微流控技术在科学界和工业界引起了相当大的兴趣：这些技术为儿科药物制剂的设计、生产和定制提供了先进的方法，能够更精确地调节剂量、提高溶解度和增加药物的可接受性。在这篇综述中，我们深入探讨了这些前沿技术及其对儿科药物制剂生产的影响。我们分析了它们的潜力、相关挑战和最新发展，全面概述了这些创新方法为制药行业带来的机遇。我们研究了使用这些技术生成的不同药物制剂，评估了它们的优缺点。
