结肠内和回肠内输注对猫胰腺外分泌的抑制作用。
Inhibition of external pancreatic secretion by intracolonic and intraileal infusions in the cat.
作者信息
Harper A A, Hood A J, Mushens J, Smy J R
出版信息
J Physiol. 1979 Jul;292:445-54. doi: 10.1113/jphysiol.1979.sp012863.
Abstract
- Infusions of oleic acid into the colon or the distal part of the ileum in anaesthetized cats inhibits secretion of water and amylase by the pancreas, stimulated by secretin and pancreozymin. Intraileal infusions of other non-water-soluble substances or hypertonic solutions can also inhibit the pancreas. 2. As inhibition can be produced after extrinsic denervation of the pancreas and gut, it must in part be humorally mediated. 3. Pentagastrin-stimulated gastric secretion of acid and pepsin is also inhibited by the intraileal infusions, but the inhibition of acid secretion is less than that of pancreatic secretion. 4. It is suggested that the physiological counterpart of the inhibitory effects induced by the infusion of non-physiological solutions into the colon or ileum is an inhibition of pancreatic secretion brought about by the cessation of intestinal absorption, which marks the completion of the post-prandial digestive process.
摘要
- 向麻醉猫的结肠或回肠远端输注油酸，会抑制由促胰液素和促胰酶素刺激引起的胰腺水和淀粉酶分泌。回肠内输注其他非水溶性物质或高渗溶液也可抑制胰腺。2. 由于胰腺和肠道去神经支配后仍可产生抑制作用，所以这种抑制作用部分必定是通过体液介导的。3. 回肠内输注也会抑制五肽胃泌素刺激引起的胃酸和胃蛋白酶分泌，但胃酸分泌的抑制程度小于胰腺分泌的抑制程度。4. 有人提出，向结肠或回肠输注非生理性溶液所诱导的抑制作用，其生理对应物是由于肠道吸收停止导致的胰腺分泌抑制，这标志着餐后消化过程的完成。
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本文引用的文献
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