胰抑素，一种存在于回肠和结肠黏膜提取物中的胰腺分泌抑制剂。
Pancreotone, an inhibitor of pancreatic secretion in extracts of ileal and colonic mucosa.
作者信息
Harper A A, Hood A J, Mushens J, Smy J R
出版信息
J Physiol. 1979 Jul;292:455-67. doi: 10.1113/jphysiol.1979.sp012864.
Abstract
- Pancreotone is a polypeptide material obtained from ileal and colonic mucosa by extraction with alcohol and subsequent precipitation by bile salts. 2. In anaesthetized cats in inhibits the actions of secretin on the pancreas, and of pancreozymin on the pancreas and gall-bladder. 3. Pancreotone has a less powerful inhibitory action on pentagastrin-stimulated gastric secretion. 4. The actions of pancreotone resemble the inhibitory effects on the pancreas and stomach of intraileal and intracolonic infusions of oleic acid and other substances in cats with the vagal and splanchnic nerves cut. Pancreotone may be the humoral mediator of these inhibitory effects. 5. A possible relationship between the actions of pancreotone and somatostatin on the stomach, and of pancreotone and pancreatic polypeptide on the pancreas, is discussed.
摘要
- 胰调节素是一种多肽物质，通过用酒精从回肠和结肠黏膜中提取，随后用胆盐沉淀而获得。2. 在麻醉猫中，它能抑制促胰液素对胰腺的作用，以及促胰酶素对胰腺和胆囊的作用。3. 胰调节素对五肽胃泌素刺激的胃酸分泌有较弱的抑制作用。4. 胰调节素的作用类似于在切断迷走神经和内脏神经的猫中，回肠内和结肠内注入油酸及其他物质对胰腺和胃的抑制作用。胰调节素可能是这些抑制作用的体液介质。5. 文中讨论了胰调节素与生长抑素对胃的作用之间，以及胰调节素与胰多肽对胰腺的作用之间可能存在的关系。
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