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1
Pancreotone, an inhibitor of pancreatic secretion in extracts of ileal and colonic mucosa.胰抑素，一种存在于回肠和结肠黏膜提取物中的胰腺分泌抑制剂。
J Physiol. 1979 Jul;292:455-67. doi: 10.1113/jphysiol.1979.sp012864.
2
Inhibition of external pancreatic secretion by intracolonic and intraileal infusions in the cat.结肠内和回肠内输注对猫胰腺外分泌的抑制作用。
J Physiol. 1979 Jul;292:445-54. doi: 10.1113/jphysiol.1979.sp012863.
3
Comparison of the effect of somatostatin on gastrointestinal function in the conscious and anaesthetized cat and on the isolated cat pancreas.生长抑素对清醒和麻醉猫的胃肠功能以及对离体猫胰腺作用的比较。
J Physiol. 1977 Jul;269(1):77-91. doi: 10.1113/jphysiol.1977.sp011893.
4
The effects of pancreotone and glucagon-like immunoreactivity on pancreatic and gastric secretion [proceedings].胰泌素和胰高血糖素样免疫活性对胰腺和胃分泌的影响[会议论文集]
J Physiol. 1978 Feb;275:50P.
5
Augmentation of secretin-induced pancreatic secretion by caerulein.蛙皮素增强促胰液素诱导的胰腺分泌。
Am J Dig Dis. 1972 Jul;17(7):643-7. doi: 10.1007/BF02231752.
6
Effect of glucagon on gastric and pancreatic secretion and peptic ulcer formation in cats.胰高血糖素对猫胃和胰腺分泌及消化性溃疡形成的影响。
Am J Dig Dis. 1974 Jun;19(6):557-64. doi: 10.1007/BF01072743.
7
A comparison of the pepsin stimulating effects of secretin preparations.促胰液素制剂的胃蛋白酶刺激作用比较。
J Physiol. 1976 Jun;258(1):63-72. doi: 10.1113/jphysiol.1976.sp011406.
8
Further purification of gastrozymin and spectrum of activities.胃蛋白酶的进一步纯化及活性谱
Scand J Gastroenterol. 1981;16(2):201-8. doi: 10.3109/00365528109181956.
9
Comparison of vasoactive intestinal peptide and secretin in stimulation of pancreatic secretion.血管活性肠肽与促胰液素对胰腺分泌刺激作用的比较
J Physiol. 1976 Feb;255(2):497-509. doi: 10.1113/jphysiol.1976.sp011292.
10
Effect of intravenous infusion of somatostatin on gastric, pancreatic and biliary secretion in the rat.静脉输注生长抑素对大鼠胃、胰腺和胆汁分泌的影响。
Gastroenterol Jpn. 1978;13(3):190-6. doi: 10.1007/BF02773663.

引用本文的文献

1
Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man.截短的胰高血糖素样肽-1（胰高血糖素原78-107酰胺）可抑制人体的胃和胰腺功能。
Dig Dis Sci. 1993 Apr;38(4):665-73. doi: 10.1007/BF01316798.
2
Effect of colectomy on cholecystokinin and gastrin release.结肠切除术对胆囊收缩素和胃泌素释放的影响。
Ann Surg. 1982 Dec;196(6):691-4. doi: 10.1097/00000658-198212001-00013.
3
Localization of peptide YY (PYY) in gastrointestinal endocrine cells and effects on intestinal blood flow and motility.肽YY（PYY）在胃肠内分泌细胞中的定位及其对肠血流量和蠕动的影响。
Proc Natl Acad Sci U S A. 1982 Jul;79(14):4471-5. doi: 10.1073/pnas.79.14.4471.
4
Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion.肽YY（PYY）的分离与特性鉴定，肽YY是一种抑制胰腺外分泌的潜在肠道激素。
Proc Natl Acad Sci U S A. 1982 Apr;79(8):2514-8. doi: 10.1073/pnas.79.8.2514.
5
Colonic inhibition of gastric secretion in man.人体结肠对胃酸分泌的抑制作用。
Dig Dis Sci. 1981 Mar;26(3):195-201. doi: 10.1007/BF01391629.
6
Exocrine pancreatic function following proximal small bowel resection in rats.大鼠近端小肠切除术后的外分泌胰腺功能
J Physiol. 1982 Jan;322:71-82. doi: 10.1113/jphysiol.1982.sp014023.
7
Effect of natural peptide YY on blood flow and exocrine secretion of pancreas in dogs.天然肽YY对犬胰腺血流及外分泌的影响。
Dig Dis Sci. 1988 Jul;33(7):828-32. doi: 10.1007/BF01550971.
8
Effect of natural peptide YY on pancreatic secretion and cholecystokinin release in conscious dogs.天然肽YY对清醒犬胰腺分泌和胆囊收缩素释放的影响。
Dig Dis Sci. 1989 Mar;34(3):468-73. doi: 10.1007/BF01536273.
9
Does the sympathetic nervous system regulate the exocrine pancreas?交感神经系统是否调节外分泌胰腺？
Int J Pancreatol. 1989 Sep;5(2):109-16. doi: 10.1007/BF02924411.
10
Long-term effect of growth promoting conditions on the exocrine pancreas of rats.促生长条件对大鼠外分泌胰腺的长期影响。
Int J Pancreatol. 1989 Jul;5(1):55-67. doi: 10.1007/BF02925698.

本文引用的文献

1
Pancreozymin, a stimulant of the secretion of pancreatic enzymes in extracts of the small intestine.促胰酶素，一种存在于小肠提取物中能刺激胰腺酶分泌的物质。
J Physiol. 1943 Jun 30;102(1):115-25. doi: 10.1113/jphysiol.1943.sp004021.
2
On the preparation of secretin and pancreozymin.关于促胰液素和缩胆囊素的制备。
J Physiol. 1949 Dec;110(3-4):367-76. doi: 10.1113/jphysiol.1949.sp004445.
3
Comparison of enterogastrone derived from various sections of the intestine.源自肠道不同部位的肠抑胃素的比较。
Gastroenterology. 1962 Oct;43:457-61.
4
[Study of the action of fats on the contraction of the gallbladder. II. Demonstration of a hormonal factor inhibiting gallbladder contraction].[脂肪对胆囊收缩作用的研究。II. 一种抑制胆囊收缩的激素因子的证明]
Nutr Dieta Eur Rev Nutr Diet. 1960;2:223-9.
5
Assay of gastrin by means of its gastric acid stimulating activity.通过胃泌素刺激胃酸分泌的活性来测定胃泌素。
J Physiol. 1968 Oct;198(3):613-26. doi: 10.1113/jphysiol.1968.sp008629.
6
Water and electrolyte secretion by the perfused pancreas of the cat.猫的灌注胰腺的水和电解质分泌
J Physiol. 1968 May;196(1):133-49. doi: 10.1113/jphysiol.1968.sp008499.
7
Influence of glucagon on pancreatic exocrine secretion in man.胰高血糖素对人体胰腺外分泌的影响。
Gastroenterology. 1970 Apr;58(4):532-9.
8
Biological assay of cholecystokinin in guinea-pig gall-bladder in situ.豚鼠原位胆囊中胆囊收缩素的生物学测定。
Acta Pharm Suec. 1969 Dec;6(6):599-606.
9
Inhibition of pancreatic exocrine secretion by intra-colonic oleic acid infusion in the dog.结肠内注入油酸对犬胰腺外分泌的抑制作用
Biomedicine. 1974 Jun 10;21(6):263-7.
10
Proceedings: Inhibition of external pancreatic secretion by extracts of ileal and colonic mucosa.研究报告：回肠和结肠黏膜提取物对胰腺外分泌的抑制作用
Gut. 1974 Oct;15(10):825.

胰抑素，一种存在于回肠和结肠黏膜提取物中的胰腺分泌抑制剂。

Pancreotone, an inhibitor of pancreatic secretion in extracts of ileal and colonic mucosa.

作者信息

Harper A A, Hood A J, Mushens J, Smy J R

出版信息

J Physiol. 1979 Jul;292:455-67. doi: 10.1113/jphysiol.1979.sp012864.

DOI:10.1113/jphysiol.1979.sp012864
PMID:385834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1280871/
Abstract
  1. Pancreotone is a polypeptide material obtained from ileal and colonic mucosa by extraction with alcohol and subsequent precipitation by bile salts. 2. In anaesthetized cats in inhibits the actions of secretin on the pancreas, and of pancreozymin on the pancreas and gall-bladder. 3. Pancreotone has a less powerful inhibitory action on pentagastrin-stimulated gastric secretion. 4. The actions of pancreotone resemble the inhibitory effects on the pancreas and stomach of intraileal and intracolonic infusions of oleic acid and other substances in cats with the vagal and splanchnic nerves cut. Pancreotone may be the humoral mediator of these inhibitory effects. 5. A possible relationship between the actions of pancreotone and somatostatin on the stomach, and of pancreotone and pancreatic polypeptide on the pancreas, is discussed.
摘要
  1. 胰调节素是一种多肽物质，通过用酒精从回肠和结肠黏膜中提取，随后用胆盐沉淀而获得。2. 在麻醉猫中，它能抑制促胰液素对胰腺的作用，以及促胰酶素对胰腺和胆囊的作用。3. 胰调节素对五肽胃泌素刺激的胃酸分泌有较弱的抑制作用。4. 胰调节素的作用类似于在切断迷走神经和内脏神经的猫中，回肠内和结肠内注入油酸及其他物质对胰腺和胃的抑制作用。胰调节素可能是这些抑制作用的体液介质。5. 文中讨论了胰调节素与生长抑素对胃的作用之间，以及胰调节素与胰多肽对胰腺的作用之间可能存在的关系。