Department of Central Laboratory, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital and Institute, Shenyang, China.
Department of Biobank, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital and Institute, Shenyang, China.
Front Cell Infect Microbiol. 2024 Mar 22;14:1280636. doi: 10.3389/fcimb.2024.1280636. eCollection 2024.
Vaginal microbiota transplantation (VMT) is a cutting-edge treatment modality that has the potential to revolutionize the management of vaginal disorders. The human vagina is a complex and dynamic ecosystem home to a diverse community of microorganisms. These microorganisms play a crucial role in maintaining the health and well-being of the female reproductive system. However, when the balance of this ecosystem is disrupted, it can lead to the development of various vaginal disorders. Conventional treatments, such as antibiotics and antifungal medications, can temporarily relieve the symptoms of vaginal disorders. However, they often fail to address the underlying cause of the problem, which is the disruption of the vaginal microbiota. In recent years, VMT has emerged as a promising therapeutic approach that aims to restore the balance of the vaginal ecosystem. Several studies have demonstrated the safety and efficacy of VMT in treating bacterial vaginosis, recurrent yeast infections, and other vaginal conditions. The procedure has also shown promising results in reducing the risk of sexually transmitted infections and preterm birth in pregnant women. However, more research is needed to establish optimal donor selection, preparation, and screening protocols, as well as long-term safety and efficacy. VMT offers a safe, effective, and minimally invasive treatment option for women with persistent vaginal problems. It could improve the quality of life for millions of women worldwide and become a standard treatment option shortly. With further research and development, it could potentially treat a wide range of other health problems beyond the scope of vaginal disorders.
阴道微生物群移植（VMT）是一种前沿的治疗方法，有可能彻底改变阴道疾病的治疗方式。阴道是一个复杂而动态的生态系统，容纳着多种微生物群落。这些微生物在维持女性生殖系统的健康和福祉方面起着至关重要的作用。然而，当这个生态系统的平衡被打破时，就会导致各种阴道疾病的发生。传统的治疗方法，如抗生素和抗真菌药物，可以暂时缓解阴道疾病的症状。然而，它们往往无法解决问题的根本原因，即阴道微生物群的失衡。近年来，VMT 作为一种有前途的治疗方法出现，旨在恢复阴道生态系统的平衡。多项研究表明，VMT 在治疗细菌性阴道病、复发性酵母菌感染和其他阴道疾病方面具有安全性和有效性。该手术还显示出在降低孕妇性传播感染和早产风险方面的良好效果。然而，仍需要更多的研究来确定最佳的供体选择、准备和筛选方案，以及长期的安全性和有效性。VMT 为患有持续性阴道问题的女性提供了一种安全、有效和微创的治疗选择。它可以提高全球数百万女性的生活质量，并有望很快成为一种标准治疗选择。随着进一步的研究和开发，它有可能治疗广泛的其他健康问题，而不仅仅是阴道疾病。
