Department of Obstetrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Community medicine department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
BMC Womens Health. 2024 Oct 26;24(1):575. doi: 10.1186/s12905-024-03418-z.
The primary goal of this study is to discern the optimal adjuvant treatment for patients diagnosed with bacterial vaginosis, focusing on reducing recurrence rates.
This study is a double-blind clinical trial with no previous similar trials conducted to date. The study population consisted of non-pregnant, married women visiting teaching hospitals' clinics in Mashhad, complaining of vaginal discharge. After informed consent and questionnaire completion, samples were obtained from vaginal discharge surrounding the cervix of clinically diagnosed bacterial vaginosis patients. Using Gram staining, a gold standard method for bacterial vaginosis diagnosis, samples were examined under a microscope according to the Nugent score. After initial treatment with metronidazole, patients were divided into two groups receiving either vaginal or oral probiotics.
Of the 55 participating women, 20 were in the vaginal probiotic group and 35 were in the oral probiotic group. No significant demographic or clinical differences existed between groups at baseline. The Nugent score decreased from 8.5 to 3 in the vaginal group and from 9 to 3 in the oral group, suggesting the effectiveness of both treatments. While the difference between groups was not statistically significant, each group showed significant improvements from their initial states (p-value < 0.001).
No significant difference was observed in the effectiveness of oral versus vaginal probiotics in reducing the recurrence of bacterial vaginosis after routine treatment. Therefore, the type of probiotic to be used could be chosen based on patient preference.
本研究的主要目标是确定细菌性阴道病患者的最佳辅助治疗方法，重点是降低复发率。
这是一项双盲临床试验，迄今为止尚无类似的试验。研究人群为非妊娠、已婚、因阴道分泌物就诊于马什哈德教学医院的妇女。在知情同意和完成问卷后，从临床诊断为细菌性阴道病患者宫颈周围的阴道分泌物中获取样本。使用革兰氏染色，这是一种细菌性阴道病诊断的金标准方法，根据 Nugent 评分在显微镜下检查样本。在初始甲硝唑治疗后，将患者分为阴道或口服益生菌组。
在 55 名参与的女性中，有 20 名在阴道益生菌组，35 名在口服益生菌组。两组在基线时在人口统计学和临床方面没有显著差异。阴道组的 Nugent 评分从 8.5 降至 3，口服组从 9 降至 3，表明两种治疗方法均有效。虽然组间差异无统计学意义，但每个组与初始状态相比均有显著改善（p 值<0.001）。
在常规治疗后，口服与阴道益生菌在降低细菌性阴道病复发方面的效果无显著差异。因此，可以根据患者的偏好选择使用哪种益生菌。
