Bogaard J M, Verheijen-Breemhaar L, Kroon T A, Hilvering C, Alcalá L S, Erdmann I M, Pattenier J W
Respiration. 1985;47(4):278-84. doi: 10.1159/000194783.
In 9 asthmatic patients log(dose)-response curves were obtained on 4 successive days with the Wiesbadener Doppelinhalator (WDI) and the De Vilbiss (De V) 645 nebulizer, respectively. log(dose)-response was expressed as a quadratic regression equation. From those equations the dose, causing a fall in response (FEV1) of 10% of the initial value, was obtained and defined as the provocative concentration (PC(10] or sensitivity. Moreover, the reactivity was defined as the slope of the linear regression through the steeper part of the curve. Although we compared the De V and the WDI log(dose)-response curves after correction for the different liquid output, a significantly greater sensitivity was found for the De V nebulizer. As to the reactivity, no significant differences were found. The difference in sensitivity could perhaps be explained by the fact that, as compared with the De V nebulizer, the WDI may cause a larger deposition of aerosol on the throat and the pharynx, due to the much greater linear velocity of its aerosol jet.
在9例哮喘患者中，分别使用威斯巴登复式雾化器（WDI）和德维比斯（De V）645雾化器，连续4天获得对数剂量-反应曲线。对数剂量-反应以二次回归方程表示。从这些方程中得出导致反应（第一秒用力呼气量，FEV1）下降至初始值的10%时的剂量，并将其定义为激发浓度（PC(10)）或敏感性。此外，反应性定义为通过曲线较陡部分的线性回归斜率。尽管在对不同液体输出进行校正后比较了De V和WDI的对数剂量-反应曲线，但发现De V雾化器的敏感性明显更高。关于反应性，未发现显著差异。敏感性的差异可能是由于与De V雾化器相比，WDI的气溶胶射流线性速度大得多，可能会在喉部和咽部产生更大的气溶胶沉积。
