Department of Midwifery, Faculty of Health Sciences, Karamanoglu Mehmetbey University, Karaman, Turkey.
Department of Gastronomy, Faculty of Tourism, Necmettin Erbakan University, Konya, Turkey.
Food Chem Toxicol. 2024 Jun;188:114653. doi: 10.1016/j.fct.2024.114653. Epub 2024 Apr 8.
Sunset Yellow (SY), an azo synthetic food dye, is widely used in the food industry. Although there are different opinions on its effect on people, its use is regulated in the European Union. If the Acceptable Daily Intake of 2.5 mg/kg/bw is exceeded, it may have pathological and biochemical effects on organs. There are not enough studies on the effects of SY on growth and development in mammals. This study was conducted to determine the effect of SY on the morphological parameters of mice at different ages (four, eight, and ten weeks old). The treatment and control groups were created with Swiss Albino mice (n: 6). SY was administered orally for 28 days (30 mg/kg/bw/week). On the last day of the study, the mice were weighed, and tail, temporal region, femur, and crown-rubmp-length values were measured using a digital caliper. A statistical difference in average body weight was observed in the SY groups (p < 0.05). SY administration during childhood caused retardation in growth and development parameters. Therefore, SY may cause weight gain and affect morphological parameters. Additional studies are required to investigate the effects of SY at different doses and durations.
日落黄（SY）是一种偶氮合成食用色素，广泛应用于食品工业。尽管人们对其对人体的影响存在不同意见，但欧盟对其使用进行了监管。如果超过 2.5mg/kg/bw 的可接受日摄入量，它可能对器官产生病理和生化影响。目前关于 SY 对哺乳动物生长发育影响的研究还不够充分。本研究旨在确定 SY 对不同年龄（四周、八周和十周）小鼠形态参数的影响。用瑞士白化小鼠（n：6）建立了实验组和对照组。SY 经口给药 28 天（每周 30mg/kg/bw）。在研究的最后一天，对小鼠进行称重，并使用数字卡尺测量尾巴、颞部、股骨和冠-臀长度值。SY 组的平均体重存在统计学差异（p<0.05）。儿童时期 SY 的给药导致生长和发育参数的延迟。因此，SY 可能导致体重增加并影响形态参数。需要进一步研究不同剂量和持续时间的 SY 对身体的影响。
