• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

鉴定头颈部鳞状细胞癌中的干性相关糖基化改变。

Identification of stemness-related glycosylation changes in head and neck squamous cell carcinoma.

机构信息

Department of Life Technologies, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.

InFLAMES Research Flagship, University of Turku, 20014, Turku, Finland.

出版信息

BMC Cancer. 2024 Apr 10;24(1):443. doi: 10.1186/s12885-024-12161-5.

DOI:10.1186/s12885-024-12161-5
PMID:38600440
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11005150/
Abstract

BACKGROUND

Altered glycosylation is a hallmark of cancer associated with therapy resistance and tumor behavior. In this study, we investigated the glycosylation profile of stemness-related proteins OCT4, CIP2A, MET, and LIMA1 in HNSCC tumors.

METHODS

Tumor, adjacent normal tissue, and blood samples of 25 patients were collected together with clinical details. After tissue processing, lectin-based glycovariant screens were performed.

RESULTS

Strong correlation between glycosylation profiles of all four stemness-related proteins was observed in tumor tissue, whereas glycosylation in tumor tissue, adjacent normal tissue, and serum was differential.

CONCLUSIONS

A mannose- and galactose-rich glycosylation niche associated with stemness-related proteins was identified.

摘要

背景

糖基化改变是癌症的一个标志，与治疗耐药性和肿瘤行为有关。在这项研究中，我们研究了与 HNSCC 肿瘤相关的干性相关蛋白 OCT4、CIP2A、MET 和 LIMA1 的糖基化谱。

方法

收集了 25 名患者的肿瘤、相邻正常组织和血液样本，并附有临床详细信息。在组织处理后，进行了基于凝集素的糖变异筛选。

结果

在肿瘤组织中观察到所有四个干性相关蛋白的糖基化谱之间存在强烈的相关性，而肿瘤组织、相邻正常组织和血清中的糖基化则存在差异。

结论

鉴定了与干性相关蛋白相关的富含甘露糖和半乳糖的糖基化小生境。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/039d/11005150/444a5a8d54ae/12885_2024_12161_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/039d/11005150/0876f9f93b28/12885_2024_12161_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/039d/11005150/0ac3d483d7bc/12885_2024_12161_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/039d/11005150/444a5a8d54ae/12885_2024_12161_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/039d/11005150/0876f9f93b28/12885_2024_12161_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/039d/11005150/0ac3d483d7bc/12885_2024_12161_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/039d/11005150/444a5a8d54ae/12885_2024_12161_Fig3_HTML.jpg

相似文献

1
Identification of stemness-related glycosylation changes in head and neck squamous cell carcinoma.鉴定头颈部鳞状细胞癌中的干性相关糖基化改变。
BMC Cancer. 2024 Apr 10;24(1):443. doi: 10.1186/s12885-024-12161-5.
2
CIP2A is an Oct4 target gene involved in head and neck squamous cell cancer oncogenicity and radioresistance.CIP2A是一种与头颈鳞状细胞癌致癌性和放射抗性相关的八聚体结合转录因子4（Oct4）靶基因。
Oncotarget. 2015 Jan 1;6(1):144-58. doi: 10.18632/oncotarget.2670.
3
CSRP2 promotes cell stemness in head and neck squamous cell carcinoma.CSRP2 促进头颈部鳞状细胞癌中的细胞干性。
Head Neck. 2023 Sep;45(9):2161-2172. doi: 10.1002/hed.27464. Epub 2023 Jul 19.
4
Wnt/β-catenin signalling maintains self-renewal and tumourigenicity of head and neck squamous cell carcinoma stem-like cells by activating Oct4.Wnt/β-catenin 信号通路通过激活 Oct4 来维持头颈部鳞状细胞癌干细胞样细胞的自我更新和致瘤性。
J Pathol. 2014 Sep;234(1):99-107. doi: 10.1002/path.4383. Epub 2014 Jul 23.
5
Notch1 signaling contributes to stemness in head and neck squamous cell carcinoma.Notch1信号传导对头颈部鳞状细胞癌的干性有促进作用。
Lab Invest. 2016 May;96(5):508-16. doi: 10.1038/labinvest.2015.163. Epub 2016 Feb 29.
6
HMGA2-Snai2 axis regulates tumorigenicity and stemness of head and neck squamous cell carcinoma.HMGA2-Snai2 轴调控头颈部鳞状细胞癌的肿瘤发生和干性。
Exp Cell Res. 2022 Sep 1;418(1):113271. doi: 10.1016/j.yexcr.2022.113271. Epub 2022 Jun 25.
7
miR-31 targets ARID1A and enhances the oncogenicity and stemness of head and neck squamous cell carcinoma.微小RNA-31靶向ARID1A并增强头颈部鳞状细胞癌的致癌性和干性。
Oncotarget. 2016 Aug 30;7(35):57254-57267. doi: 10.18632/oncotarget.11138.
8
Cisplatin overcomes radiotherapy resistance in OCT4-expressing head and neck squamous cell carcinoma.顺铂克服 OCT4 表达的头颈部鳞状细胞癌的放射抵抗。
Oral Oncol. 2022 Apr;127:105772. doi: 10.1016/j.oraloncology.2022.105772. Epub 2022 Mar 1.
9
Copy number increase of oncoprotein CIP2A is associated with poor patient survival in human head and neck squamous cell carcinoma.癌蛋白CIP2A的拷贝数增加与人类头颈部鳞状细胞癌患者的不良生存相关。
J Oral Pathol Med. 2016 May;45(5):329-37. doi: 10.1111/jop.12372. Epub 2015 Oct 5.
10
Comprehensive investigation into the influence of glycosylation on head and neck squamous cell carcinoma and development of a prognostic model for risk assessment and anticipating immunotherapy.全面研究糖基化对头颈部鳞状细胞癌的影响，并开发一种用于风险评估和预测免疫治疗的预后模型。
Front Immunol. 2024 Mar 18;15:1364082. doi: 10.3389/fimmu.2024.1364082. eCollection 2024.

引用本文的文献

1
Evaluation of Integrin Glycovariants as Biomarkers of Metastasis, Invasion, and Therapy Stratification in Head and Neck Squamous Cell Carcinoma.整合素糖变体作为头颈部鳞状细胞癌转移、侵袭和治疗分层生物标志物的评估
Cancer Med. 2025 May;14(9):e70717. doi: 10.1002/cam4.70717.

本文引用的文献

1
Comprehensive Glycoprofiling of Oral Tumors Associates N-Glycosylation With Lymph Node Metastasis and Patient Survival.口腔肿瘤的综合糖组学分析将 N-糖基化与淋巴结转移和患者生存相关联。
Mol Cell Proteomics. 2023 Jul;22(7):100586. doi: 10.1016/j.mcpro.2023.100586. Epub 2023 Jun 1.
2
Aberrant glycosylation of α3 integrins as diagnostic markers in epithelial ovarian cancer.α3 整合素异常糖基化作为上皮性卵巢癌的诊断标志物。
Clin Chim Acta. 2023 Mar 15;543:117323. doi: 10.1016/j.cca.2023.117323. Epub 2023 Mar 30.
3
Reviewing the epidemiology of head and neck cancer: definitions, trends and risk factors.
头颈部癌症的流行病学回顾：定义、趋势和危险因素。
Br Dent J. 2022 Nov;233(9):780-786. doi: 10.1038/s41415-022-5166-x. Epub 2022 Nov 11.
4
Head and neck cancer N-glycome traits are cell line and HPV status-dependent.头颈部癌症 N-糖组学特征与细胞系和 HPV 状态有关。
Anal Bioanal Chem. 2022 Dec;414(29-30):8401-8411. doi: 10.1007/s00216-022-04376-x. Epub 2022 Oct 27.
5
Identifying SNARE Proteins Using an Alignment-Free Method Based on Multiscan Convolutional Neural Network and PSSM Profiles.基于多扫描卷积神经网络和 PSSM 图谱的无对齐方法鉴定 SNARE 蛋白。
J Chem Inf Model. 2022 Oct 10;62(19):4820-4826. doi: 10.1021/acs.jcim.2c01034. Epub 2022 Sep 27.
6
Exposure to alcohol and overall survival in head and neck cancer: A regional cohort study.头颈部癌症中接触酒精与总生存：一项区域性队列研究。
Head Neck. 2022 Oct;44(10):2109-2117. doi: 10.1002/hed.27125. Epub 2022 Jun 17.
7
Diagnostic potential of nanoparticle aided assays for MUC16 and MUC1 glycovariants in ovarian cancer.纳米颗粒辅助检测试剂盒对卵巢癌 MUC16 和 MUC1 糖型变体的诊断潜力。
Int J Cancer. 2022 Oct 1;151(7):1175-1184. doi: 10.1002/ijc.34111. Epub 2022 May 25.
8
Comprehensive Analysis of the Potential Prognostic Value of 11 Glycosylation-Related Genes in Head and Neck Squamous Cell Carcinoma and Their Correlation with PD-L1 Expression and Immune Infiltration.11个糖基化相关基因在头颈部鳞状细胞癌中的潜在预后价值及其与PD-L1表达和免疫浸润的相关性综合分析
J Oncol. 2022 Apr 14;2022:2786680. doi: 10.1155/2022/2786680. eCollection 2022.
9
Cisplatin overcomes radiotherapy resistance in OCT4-expressing head and neck squamous cell carcinoma.顺铂克服 OCT4 表达的头颈部鳞状细胞癌的放射抵抗。
Oral Oncol. 2022 Apr;127:105772. doi: 10.1016/j.oraloncology.2022.105772. Epub 2022 Mar 1.
10
Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism.利马 1 介导膜动力学和细胞代谢的多能性控制。
Nat Commun. 2022 Feb 1;13(1):610. doi: 10.1038/s41467-022-28139-5.