The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Lipids Health Dis. 2024 Oct 10;23(1):331. doi: 10.1186/s12944-024-02325-4.
Abdominal obesity, a significant risk factor for the progression of diabetic retinopathy (DR), may lead to improved visual outcomes through early assessment. This study aims to evaluate any potential associations between DR and novel lipid metabolism markers, including the Atherogenic Index of Plasma (AIP), Visceral Adiposity Index (VAI), and Lipid Accumulation Product (LAP).
This study aimed to elucidate the association between various lipid markers and DR by screening the National Health and Nutrition Examination Survey (NHANES) database in the United States from 2005 to 2008. To examine the correlation, multifactor logistic regression analysis, subgroup analysis, threshold effect analysis, interaction test, and smooth curve fitting were used.
Among the 2591 participants included, the incidence of DR was 13.6% and the mean age was 59.55 ± 12.26 years. After adjusting for important confounding covariates, logistic regression studies suggested a possible positive association between LAP, VAI, AIP, and DR occurrence (odds ratio [OR] = 1.004; 95% confidence interval [CI]: 1.002, 1.006; P < 0.0001; [OR] = 1.090; 95% [CI]: 1.037, 1.146; P = 0.0007; [OR] = 1.802; 95% [CI]: 1.240, 2.618; P = 0.0020). The nonlinear association between LAP and DR was further illustrated using an S-shaped curve by smoothing curve fitting, with the inflection point of the curve located at 63.4. Subgroup analyses and interaction tests were performed with full variable adjustment (P > 0.05 for all interactions).
Studies have shown that elevated levels of LAP, VAI, and AIP increase the likelihood of DR, suggesting that they have the potential to be predictive markers of DR, emphasizing their potential utility in risk assessment and prevention strategies, and advocating for early intervention to mitigate the likelihood of DR.
腹部肥胖是糖尿病视网膜病变（DR）进展的一个重要危险因素，通过早期评估可能会改善视力结果。本研究旨在评估新型脂质代谢标志物（包括血浆致动脉粥样硬化指数（AIP）、内脏脂肪指数（VAI）和脂质蓄积产物（LAP））与 DR 之间的潜在关联。
本研究旨在通过筛查美国 2005 年至 2008 年国家健康和营养检查调查（NHANES）数据库来阐明各种脂质标志物与 DR 之间的关联。为了检验相关性，使用多因素逻辑回归分析、亚组分析、阈值效应分析、交互检验和光滑曲线拟合。
在纳入的 2591 名参与者中，DR 的发生率为 13.6%，平均年龄为 59.55±12.26 岁。在调整了重要混杂协变量后，逻辑回归研究表明 LAP、VAI、AIP 与 DR 发生之间可能存在正相关（比值比[OR]＝1.004；95%置信区间[CI]：1.002，1.006；P<0.0001；OR＝1.090；95%CI：1.037，1.146；P＝0.0007；OR＝1.802；95%CI：1.240，2.618；P＝0.0020）。通过光滑曲线拟合进一步说明了 LAP 与 DR 之间的非线性关联，曲线的拐点位于 63.4。进行了亚组分析和交互检验，均进行了全变量调整（所有交互作用 P>0.05）。
研究表明，LAP、VAI 和 AIP 水平升高会增加 DR 的发生风险，这表明它们可能成为 DR 的预测标志物，强调了它们在风险评估和预防策略中的潜在应用价值，并提倡早期干预以降低 DR 的发生可能性。
